Abstract： Objective To observe the effect of combined leflunomide and benazepril therapy on proteinuria and renal function in experimental progressive Thy-1 glomerulonephritis rats. Methods After one-side renal ablation, the surviving male Wistar rats were randomly assigned to five groups: one-side renal ablation group, untreated group(model group), leflunomide treated group, benazepril treated group, and leflunomide plus benazepril treated group . OX7（100 mg/kg）was injected into these groups except one side renal ablation group through the caudal vein three days after renal ablation, and then OX7 antibody was injected once a week, for three times. Distilled water or medicine was administered respectively by gavage for a period of 12 weeks. The general status, body weight, proteinuria(UP), serum creatinine(Scr), glomerular and tubulointerstitial histological damage scores were also measured. Results At the end of 12 week treatment, leflunomide treated group, benazepril treated group and leflunomide plus benazepril treated group showed reduced 24 h UP, Scr and smaller scores of glomerular and tubulointerstitial histological damage compared with model group. Compared with leflunomide treated group and benazepril treated group, leflunomide plus benazepril treated group showed smaller 24h UP, Scr and scores of glomerular and tubulointerstitial histological damage. Conclusions Combined leflunomide and benazepril therapy reduces 24h UP and Scr in experimental progressive Thy-1 glomerulonephritis rats and slows the progression of chronic renal injury.
2012, Vol. 23 
