Abstract：Objective To investigate the clinical characteristics and treatment of gastric stromal tumors(GST). Methods The clinical data of patients with proved pathologically gastric stromal tumors admitted from January 2010 to January 2012 were analyzed retrospectively. Results The tumors originated from gastric antrum（n=15）, gastric corpus(n=11),and gastic fundus(n=8), separately.The clinical manifestations found in patients with GST included abdominal discomfort or pain(n=11), abdominal mass(n=14), gastrointestinal bleeding or melena(n=5),and 4 cases were found in physical examination or other surgery (n=4).All the GSTs in this group underwent operation and pathological examination . Immunohistochemical determination revealed that the positive rates of CD117 and CD34 were 94.1% and 73.5% respectively. 32 cases were followed up and 4 cases of recurrent GST received imatinib mesylate therapy. Conclusions The diagnosis of GST should be confirmed by postoperative pathological and immunohistochemical examination Surgery is the main therapy and appropriate targeted therapy improves the survival.
2012, Vol. 23 
