Abstract:Objective To investigate the efficacy of treating premature ejaculation with a highly selective α1-adrenergic receptor blocker in combination with dorsal penile nerve amputation surgery. Methods 89 patients with premature ejaculation were randomly divided into three groups: simple drug treatment group, simple dorsal penile nerve transection group, the combined treatment group. Patients in each group were given appropriate treatment to observe changes in ejaculation latency. Results The ejaculatory latency of combined therapy group was significantly prolonged (P <0.01)compared with the simple drug treatment group and the dorsal penile nerve transection group. Conclusion Dorsal penile nerve amputation surgery combined with α1-adrenergic receptor blocker is an effective treatment of premature ejaculation.