Clinical analysis of diltiazem hydrochloride combined with nitroglycerin in the treatment of unstable angina pectoris
LIU Qing1,LI Huifang2,Liu Lifeng1,and DONG Lijin3.
1. Department of Pharmacy, 2. Department of Cardiology, Shanxi Provincial Crops Hospital, Chinese People’s Armed Police Forces, Taiyuan 030006, China; 3. The Logistic University of Chinese People’s Armed Police Forces, Tianjin 300162, China
Abstract：Objective To observe the efficacy of injection of diltiazem hydrochloride combined with nitroglycerin in the treatment of unstable angina pectoris. Methods 101 patients with unstable angina pectoris in our hospital were randomly divided into test group (n=51) and control group (n= 50). The test group was administered with diltiazem hydrochloride in combination with nitroglycerin while the control group was given nitroglycerin alone. After 48 hours, the two groups of patients were observed and compared in terms of anginal attacks, heart rate, PR, QRS, QT interval time, blood pressure, myocardial oxygen consumption index, blood routine, blood biochemical index. Results There was no death, no complications or significant arrhythmias and hemodynamic changes. After treatment, the heart rate and myocardial oxygen consumption index of the test group decreased more significantly (P <0.05)than in the control group. PR interval and QT interval of the test group were slightly longer than those of the control group, but without significant difference. Conclusion Injection of diltiazem hydrochloride combined with nitroglycerin in the treatment of unstable angina pectoris patients induces no serious adverse reactions and can effectively relieve angina, significantly reduce myocardial oxygen consumption and provide better myocardial protection.
2012, Vol. 23 
