Abstract：Objective To evaluate the efficacy and safety of administration of dexmedetomidine and propofol in pediatric patients who need a preoperative stereotaxis procedure using magnetic resonance imaging (MRI). Methods 100 pediatric patients needing stereotaxic check by MRI under basic anesthesia were randomly divided into two groups. All subjects were given ketamine 1-2 mg/kg to get thorough sedation. The maintenance dose of dexmedetomidine in group Ⅰwas 1.0 μg/(kg·h), and propofol in group Ⅱwas 6 mg/(kg·h). After they fell asleep, all subjects were given local anesthesia to put on the stereotaxic instrument. Patients’ MBP, HR and SPO2 were recorded at several necessary time points . Patients who needed additional propofol and patients’ recovery time were recored. Additionally, we also observed the incidence of adverse events such as respiratory depression, unexpected early recovery and postoperative agitation. Results Compaired with group Ⅰ,the cases who needed additional propofol and the subjects who had respiratory depression were significantly increased in group Ⅱ (P<0.01 ). The heart rate dropped somewhat during the checking time in group Ⅰ, but still within the normal range (P>0.05). There was no significant difference in postoperative recovery status between these two groups. Conclusions During stereotaxic checking period by MRI in pediatric patients, the maintenance dose 1 μk/(kg·h) of dexmedetomidine after a loading dose of ketamine 1-2 mg/kg can not only reduce the additional injection of propofol, but also ensure the children’s quietness and safety without respiratory depression.
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2013, Vol. 24 
