Effects of high dose radiotherapy combined with osteoclast inhibitors on pain caused by osseous metastasis
WU Lizhou1,JIANG Mingdong2,YANG Wanyi2,FANG Liang2,and WANG Zhenghong2
WU Lizhou1, JIANG Mingdong2, YANG Wanyi2, FANG Liang2, and WANG Zhenghong2. 1.Tumor Radiotherapy Center, Jiangsu Provincial Corps Hospital of Chinese People’s Armed Police Forces, Yangzhou 225003, China; 2. Tumor Hematology and Radiation Therapy Center, Chongqing Ninth People’s Hospital, Chongqing 400700, China
Abstract：Objective To investigate the clinical effects of high dose radiotherapy combined with osteoclast inhibitors on pain caused by osseous metastasis. Methods 550 malignant tumor patients were divided into treatment group(n=300) and control group(n=250).Treatment group was given high dose radiotherapy combined with osteoclast inhibitors.The control group was only received osteoclast inhibitors or else drugs. Results The efficiency of partial response plus complete response was significantly higher in treatmen group than those in control group (75.6% vs 39.60%, P<0.05). And the long-term response rate was also better than that in control group (85.6% vs 48.8%, P<0.05). Conclusions High dose radiotherapy combined with osteoclast inhibitors has good short and long-term clinical efficacy for pain caused by osseous metastasis.
2014, Vol. 25 
