1.Department of Cardiogy, Heilongjiang Provincial Corps Hospital, Chinese People’s Armed Police Forces, Harbin 150076, China; 2.Department of Cardiology, General Hospital of Chinese People’s Armed Police Forces, Beijing 10039, China
Abstract：Objective To study the effects of losartan combined with atorvastatin on the endothelial function and arterial elasticily elasticity in patients with diabetic nephropathy. Methods A total of 65 patients with diabetic nephropathy were enrolled and randomized to losartan group (only losartan 50 mg/d), atrovastatin group (only atorvastatin 20 mg/d) and combined group (losartan 50 mg/d+atorvastatin 20 mg/d) by envelopes. The brachial artery flow-mediated dilation (FMD) and brachial-ankle pulse wave velocity (baPWV) were compared among the three groups during six-month follow-up. Results After six-month follow-up, the levels of FMD(10.61?0.52) and baPWV (8.56?0.44 cm/s) in the combined group improved much more significantly than those in losartan group[FMD: (7.28?0.59); baPWV: (10.8?0.62) cm/s] or atrovastatin group[FMD: (6.87?0.62); baPWV: (11.2?0.41) cm/s] (P<0.05). Conclusions Losartan combined with atorvastatin benefits the endothelial function and arterial elasticity in diabetic nephropathy.
周秀荣,杨勇,曹茂荣,罗建平. 氯沙坦联合阿托伐他汀对糖尿病肾病内皮功能及血管弹性的影响[J]. , 2014, 25(5): 468-471.
ZHOU Xiurong,YANG Yong,CAO Maorong,LUO Jianping. Effect of losartan combined with atorvastatin on endothelial function and arterial elasticity in diabetic nephropathy. , 2014, 25(5): 468-471.
2014, Vol. 25 
