摘要 目的应用Tei指数评价川崎病(kawasaki disease,KD)患儿心脏功能,探讨其临床意义。方法超声心动图测量KD急性期和恢复期患儿62例的左室射血分数(EF)、左室短轴缩短率(FS)、二尖瓣口舒张期血流E/A比值、肺静脉血流S/D比值、左右心室等容收缩期(ICT)、等容舒张期(IRT)、射血时间(ET)和计算左、右心室Tei指数,并与80例年龄、性别匹配的健康儿童作比较。结果KD急性期左心室Tei指数较健康儿童明显增高(0.43±0.07 vs 0.37±0.06,P<0.01),恢复期组左心室Tei指数减低,接近健康儿童(0.40±0.09 vs 0.37±0.06),差异无统计学意义;KD急性期右心室Tei指数增加,与健康对照组相比差异有统计学意义(0.31±0.06 vs 0.25±0.05,P<0.01),恢复期组右心室Tei指数减低,逐渐接近正常(0.30±0.08 vs 0.25±0.05),差异无统计学意义。结论KD急性期患儿存在心脏整体功能异常,Tei指数能准确、敏感地评价患儿心脏整体功能。
Abstract：Objective To investigate the clinical value of Tei index in the myocardial function in patients with Kawasaki disease(KD). Methods In the prospective study, 50 patients underwent echocardiogramphic evaluation. The left ventricular ejection fraction (EF), shortening fraction (FS), peak E/A ratio at mitral valve (E/A), peak S/D ratio of pulmonary venous flow (S/D), isovolumetric continuaction time (ICT), isovolumetric relaxation time (IRT) and ejection time (ET) were measured. Tei index was calculated. As a control, we also assessed 72 healthy children, matched for age and sex with the study population. Results Compared with the control group, left ventricular Tei index was significantly increased in the children with acute KD guoup (0.44±0.07 vs 0.37±0.05,P＜0.01). Tei index of KD group in convalescent stage was decreased (0.40±0.09 vs 0.37±0.05, P>0.05). Right ventricular Tei index was also significantly increased in the children with acute KD guoup (0.44±0.07 vs 0.37±0.05,P＜0.01) compared with the healthy children. And during the convalescent stage, the right ventricular Tei index tended to normal. Conclusions The ventricular global function was impaired in children with acute KD. Tei index is a accurate and sensitive tool for estimating global myocardial dysfunction in KD patients.
李梅,刘俊琪,张晓蓉,薛利芳. Tei指数评价川崎病患儿心脏功能的临床意义[J]. , 2014, 25(7): 681-684.
LI Mei,LIU Junqi,ZHANG Xiaorong,XUE Lifang. Evaluation of myocardial function impairment using the Tei index in patients with Kawasaki disease. , 2014, 25(7): 681-684.
2014, Vol. 25 
