Abstract：Objective To analyze the effect and existing problems of individualized comprehensive treatment of children’s retinoblastoma (RB). Methods Based on the general condition and clinical staging of 59 child patients (75 eyes) with RB, their curative effect and existing problems of individualized comprehensive treatment were analyzed. Results RB children’s initial symptoms were common: leukocoria in 35 cases (60%), strabismus in 12 cases (20%), conjunctival congestion in 6 cases (10%), decreased vision in 3 patients (5%), exophthalmus in 3 cases (5%). In 59 children with RB, their intraocular stage three-year survival rate was 90% (43/48), extraocular period survival rate was 45% (5/11), overall survival rate was 81% (48/59). Of the 75 affected eyes, the total preserved eye rate was 41.3% (31/75), including A - C stage preserved eye rate of 100%, D stage preserved eye rate of 68% (17/25), E stage preserved eye rate of 13.8% (4/29). Two extraocular RB patients because of large size of tumor could not do surgery, nine extraocular stage patients underwent successful surgical removal of the tumor, the surgical resection rate was 82%. Conclusions Individualized comprehensive treatment of RB can improve the survival rate of children and the recovery rate of eye, but the eye removal rate in E period children is still high. The management of child patients with extraocular period RB is important and difficult.
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2015, Vol. 26 
