Abstract：Objective To evaluate the clinical efficacy and adverse reaction of antigen-loaded dendritic cells(DC)vaccine in combination with cytokine-induced killer cells(CIK), gamma delta receptors of T cells(γδT)and natural killer cells(NK)on 24 patients with lung cancer. Methods Mononuclear cells isolated by blood apheresis were induced into productions of DC, γδT, CIK and NK cells by corresponding cytokines in vitro. All patients received a course of treatment including intravenous infusion and intradermal injection of DC vaccine for four times, intravenous infusion of γδT, CIK each 3 times and intravenous infusion of NK cells twice, a total of 12 times. Clinical and immunologic responses were evaluated by imaging examination,T lymphocytes subset changes, respectively. Results 22 patients were enrolled in this study. During 5-24 months follow-up(median,10 months),partial remission(PR)in 9 cases,stability of disease(SD) in 11 cases,and progression of disease(PD) in 2 cases was identified with measurable diseases progress. After 2 months treatment,the levels of CD3+、CD4+、CD56+ increased very significantly(P<0.001). No severe adverse events were observed except 2 patients with mild fever and 1 patient had muscular soreness. Conclusions Antigen-pulsed DCs in combination with various T cells shows short-term efficacy on lung cancer through inducing specific antitumor immunity.
王作志, 解尚云, 刘庆云, 魏长宏, 卞晓山. 负载抗原的DC疫苗联合多种T细胞治疗非小细胞肺癌的近期疗效与不良反应[J]. 武警医学, 2015, 26(3): 276-279.
WANG Zuozhi, XIE Shangyun, LIU Qingyun, WEI Changhong, BIAN Xiaoshan. Efficacy and adverse reactions of antigen-loaded dendritic cell vaccine in combination with various T cells on nonsmall-cell lung cancer. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(3): 276-279.
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