冠心病不同分支病变对血清新喋呤、同型半胱氨酸及基质金属蛋白酶的影响

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摘要目的探讨冠状动脉粥样硬化性心脏病(简称冠心病)不同分支病变对血清新喋呤(neopterin, Np)、同型半胱氨酸及基质金属蛋白酶的影响。方法选择冠心病148例,根据病变分支数量分为单支组、双支组、多支组,分别有58例、53例、37例。检测血清Np、Hcy及MMP-2、MMP-9、TIMP-2水平,并比较各组中的差别及分析它们之间的相关性。结果多支组Np[(12.45±3.09)nmol/L] 和Hcy[(23.71±4.57) μmol/L]均高于单支、双支组,双支组Hcy还高于单支组,差异均有统计学意义(P<0.05)。双支组MMP-2[(49.83±7.64)ng/L]、MMP-9[(194.81±17.58)ng/L]较单支组均高,而TIMP-2[(283.70±23.45)ng/L]较单支组则低,差异有统计学意义(P<0.05)。多支组MMP-2[(63.42±8.59)ng/L]、MMP-9[(249.73±24.16)ng/L]、TIMP-2[(205.61±17.32)ng/L]较单支、双支组变化更加明显,差异有统计学意义(P<0.05)。Np与MMP-9呈正相关(P<0.05),而与TIMP-2呈负相关 (P<0.05);Hcy与MMP-2、MMP-9呈正相关(P<0.05),而与TIMP-2呈负相关(P<0.05)。结论 Hcy与Np是反映冠状动脉粥样硬化范围增加的重要因素,且与反映冠状动脉重构相关的MMPs家族密切相关。

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关键词 ：冠心病, 新喋呤, 同型半胱氨酸, 基质金属蛋白酶

Abstract：Objective To investigate the effects of serum neopterin and homocysteine levels on substrate metals protease in patients with coronary heart disease in different branches. Methods 148 coronary heart disease patients were divided into single lesion group and double branch lesion group, multivessel lesions group, 58, 53, and 37 cases, respectively. Blood was sampled to detect Hcy, Np, MMP-2, MMP-9 and TIMP-2 levels. Results Hcy in duble lesion group was significantly higher than in single lesion (P<0.05), Np [(12.45±3.09)nmol/L] and Hcy [(23.71±4.57) μmol/L] in multilesion group showed significant increase than in the groups A and B (P<0.05). MMP-2[(49.83±7.64)ng/L], and MMP-9[(194.81±17.58)ng/L] in double lesion group were significantly higher than in single lesion group (P<0.05), TIMP-2 [(283.70±23.45)ng/L] in double lesion group significantly decreased (P<0.05). MMP-2 [(63.42±8.59)ng/L], MMP-9 [(249.73±24.16) ng/L] and TIMP-2 [(205.61±17.32)ng/L] in multilesion group were significantly different from the single and double lesion groups (P<0.05). Np and MMP-9 showed significant positive correlation (P<0.05), and TIMP-2 showed significantly negative correlation (P<0.05), Hcy and MMP-2 and MMP-9 showed significantly positive correlation (P<0.05), and TIMP-2 showd significantly negative correlation (P<0.05). Conclusions Np and Hcy are closely related to the field of coronary heart disease, which are closely related to MMPs indicating the progression of coronary atherosclerosis.

Key words： coronary heart disease neopterin homocysteine matrix metalloproteinases

收稿日期: 2014-08-27

ZTFLH:

R543.3

通讯作者: 贾晓炜,E-mail:ywljxwgg@163.com

作者简介: 许霞,本科学历,技师,E-mail:youyoucrh@sina.cn

引用本文:

许霞, 白晓, 贾晓炜. 冠心病不同分支病变对血清新喋呤、同型半胱氨酸及基质金属蛋白酶的影响[J]. 武警医学, 2015, 26(3): 256-258. XU Xia, BAI Xiao, JIA Xiaowei. Effects of serum neopterin and homocysteine levels on substrate metals protease in patients with coronary heart disease in different branches. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(3): 256-258.

链接本文:

http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2015/V26/I3/256

[1]	Pita-Fernandez S, Choucino-Fernandez T, Juega-Puig J, et al. A randomized clinical trial to determine the effect of angiotensin inhibitors reduction on creatinine clearance and haemoglobin in heart failure patients with chronic kidney disease and anaemia [J]. Int J Clin Pract, 2014,25(1):63-71.
[2]	Song I U, Kim J S, Park I S, et al. Clinical significance of homocysteine (hcy) on dementia in Parkinson’s disease (PD)[J]. Arch Gerontol Geriatr, 2013, 57(3): 288-291.
[10]	Kotani T, Takeuchi T, Takai S, et al. Serum levels of matrix metalloproteinase (MMP) 9, a risk factor for acute coronary syndrome, are reduced independently of serum MMP-3 by anti-TNF-alpha antibody (infliximab) therapy in patients with rheumatoid arthritis[J]. J Pharmacol Sci, 2012, 120(1): 50-53.
[3]	Hou Z H, Lu B, Gao Y, et al. Matrix metalloproteinase-9 (MMP-9) and myeloperoxidase (MPO) levels in patients with nonobstructive coronary artery disease detected by coronary computed tomographic angiography [J]. Acad Radiol, 2013, 20(1): 25-31.
[4]	Gostiljac D, Dordevic P B, Djuric D, et al. The importance of defining serum MMP-9 concentration in diabetics as an early marker of the rupture of atheromatous plaque in acute coronary syndrome [J]. Acta Physiol Hung, 2011, 98(1): 91-97.
[11]	王斌,王盼. 硒的功能与心血管疾病的研究进展[J]. 国外医学(医学地理分册),2013,34(1):20-23.
[12]	Shalia K K, Shah V K, Mashru M R, et al. Matrix metalloproteinase-3 (MMP-3) -1612 5A/6A promoter polymorphism in coronary artery disease in Indian population[J]. Indian J Clin Biochem, 2010,25(2):133-140.
[5]	Mendy V L, Azevedo M J, Sarpong D F, et al. The Association between individual and combined components of metabolic syndrome and chronic kidney disease among African Americans: the Jackson heart study [J]. PLoS One, 2014, 9(7): 815-823
[6]	姚志勇. 镉的生物毒性及对心肌细胞损伤机制的研究进展[J]. 国外医学(医学地理分册), 2013, 34(2): 133-136.
[7]	Kuyumcu M E, Yesil Y, Ozturk Z A, et al. The association between homocysteine (hcy) and serum natural antioxidants in elderly bone mineral densitometry (BMD) [J]. Arch Gerontol Geriatr, 2012, 55(3): 739-743.
[8]	Guo C, Zhang S, Zhang J, et al. Correlation between the severity of coronary artery lesions and levels of estrogen, hs-CRP and MMP-9[J]. Exp Ther Med, 2014, 7(5): 1177-1180.
[9]	Li M, Shi J, Fu L, et al. Genetic polymorphism of MMP family and coronary disease susceptibility: a meta-analysis [J]. Gene, 2012, 495(1): 36-41.
[10]	Kotani T, Takeuchi T, Takai S, et al. Serum levels of matrix metalloproteinase (MMP) 9, a risk factor for acute coronary syndrome, are reduced independently of serum MMP-3 by anti-TNF-alpha antibody (infliximab) therapy in patients with rheumatoid arthritis[J]. J Pharmacol Sci, 2012, 120(1): 50-53.
[11]	王斌,王盼. 硒的功能与心血管疾病的研究进展[J]. 国外医学(医学地理分册),2013,34(1):20-23.
[12]	Shalia K K, Shah V K, Mashru M R, et al. Matrix metalloproteinase-3 (MMP-3) -1612 5A/6A promoter polymorphism in coronary artery disease in Indian population[J]. Indian J Clin Biochem, 2010,25(2):133-140.