Curative effect of low dose olanzapine combined with duloxetine in treatment of depression with pain symptoms
ZHOU Lei1,MA Rui2, ZHANG Ying1,CAO Lei1,LIU Baichuan3, LI Dehui1
1. Department of Mental Health,3. Medical Department,Jilin Provincal Corps Hospital,Chinese People’s Armed Police Forces,Changchun 130052,China; 2. Psychology Department,the Sixth Hospital of Changchun City,Changchun 130052,China
Abstract：Objective To study the curative effect of low dose olanzapine combined with duloxetine in the treatment of depression with pain symptoms. Methods 70 patients with pain symptoms of depression were randomly divided into study group (35 cases, duloxetine combined with small dose olanzapine) and control group (35 cases, duloxetine therapy), for a course of six weeks. Before treatment and after treatment, Hamilton depression scale (HAMD) and the Medical Outcomes Study Pain Measurement scale (MOSPM) were used to assess curative effect. TESS evaluation of drug side effects was performed. Results In the two groups, HAMD scores at the end of 2 week began to exhibit difference (P<0.05). At the ends of 4 weeks and 6 weeks, scores were significantly different between the two groups (P<0.01). In the two groups, MOSPM score points, at the end of 4 weeks, began to be statistically significant (P<0.05), at the end of 6 weeks, in the two groups, MOSPM score had significant difference (P<0.01). In the two groups, adverse reaction scale (TESS) score had no significant difference (P>0.05). The study group, at the end of 6 week, showed the efficiency of 71.43%, effective rate of 88.57%. The control group, at the end of 6 weeks showed efficiency, of 62.85%, effective rate of 85.71%. Compare is on of curative effect botween the two groups exhibited statistically significant difference (P<0.05). Conclusions Duloxetine combined with low dose olanzapine for treatment of depression with pain symptoms is superior to the single drug.
2015, Vol. 26 
