Abstract：Objective To study the serum ascites albumin gradient(SAAG) in patients with portal hypertensive gastropathy(PHG) and evaluate the relationship between PHG and SAAG. Method 127 patients with cirrhotic ascites were divided into PHG group and non-PHG group and their SAAG were comparatively analyzed. The relationship of SAAG between the Child-Pugh classification, MELD score, degree of esophageal varices, portal vein diameter and platelet count to spleen size ratio were analyzed in PHG group. The SAAG was analyzed contrastively on both mild and severe cases in PHG group. The receiver operating characteristic(ROC) curve was drawn to determine the optimal diagnosis threshold value of SAAG for PHG. Results The difference was statistically significant in SAAG between PHG group and non-PHG group. The SAAG was positively correlated with the Child-Pugh classification, MELD score and degree of esophageal varices in PHG group. Also there was statistical significance in diameter of portal vein and platelet count to spleen size ratio for SAAG at different levels, as well as the difference between mild and severe cases of SAAG. By using ROC curve, the optimal diagnosis threshold value of SAAG for PHG was shown to be 18.57 g/L, and sensitivity and specificity be 72.1% and 93.2%. Conclusions SAAG reflects the degree of portal hypertension in the course of PHG. SAAG is of clinical value for prediction of occurrence, judgment of the prognosis of PHG.
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2015, Vol. 26 
