Occurrence and risk factors of hyperhomocysteine in railway workers
ZHU Chunhong1, ZHANG Fan1, LEI Lianhui2, SHI Bin3, and YANG Yang3
1.Department of Disease Control and Prevention, Huicheng Gate Clinic, Beijing Railway Center Health and Epidemic Prevention Station,Beijing 100038,China; 2.The Third Department of ICU, 3.Department of Liver Transplantation,the Third Medical Center of PLA General Hospital, Beijing 100039, China
Abstract：Objective To explore the related risk factors for the occurrence of HCY so as to provide reference for the prevention and control of cardiovascular and cerebrovascular diseases.Methods A total of 76,456 railway workers who underwent physical examination in our center from March 2017 to December 2018 were selected. A total of 68,383 subjects were included according to exclusion criteria and selection criteria. Medical data including previous disease, family history of disease, tobacco and alcohol addiction was collected. Height, weight, systolic and diastolic blood pressure were measured and body mass index was calculated. FBG, TC, TG, LDL-C, HDL-C, HCY, uric acid and other indicators were detected. The differences of the above indexes of HCY at different levels as well as the differences of HCY under different risk factors were analyzed and compared. Multiple linear regression analysis of HCY and influencing factors was conducted by using the stepwise regression method, and the correlations were determined.Results The number of employees with normal HCY was 42,929 (62.78%), compared with 25,454 (37.22%)employees with elevated HCY.There was statistically significant difference in age, percentage of males, past history of cardiovascular and cerebrovascular diseases, past history of hypertension, percentage of smokers, percentage of alcohol drinkers, BMI, SBP, DBP, TG, LDL-C and UA between the two groups (P<0.05). The mean value of HDL-C in the elevated HCY group was lower than that of the normal group (P<0.05). The serum HCY levels in overweight and obese groups were significantly higher than those in the normal weight group, and the serum HCY levels tended upward (P<0.001). Serum HCY levels in the first-grade hypertension group, the second-grade hypertension group and the third-grade hypertension group were significantly higher than those in the normal weight group (P<0.001). Multiple linear regression analysis showed that there was a linear relationship between sex, smoking, elevated UA, third-grade hypertension, age (53-60 years old), secondary hypertension, alcohol consumption, history of hypertension, elevated TG, decreased HDL-C and elevated HCY (F=706059.453, P<0.001).Conclusions Gender, smoking, blood uric acid, hypertension, age, alcohol consumption, and low-density lipoprote in cholesterol are influencing factors of hyperhomocysteinemia.
朱春红, 张帆, 雷联会, 史斌, 杨洋. 铁路职工高同型半胱氨酸血症发生情况及危险因素探讨[J]. 武警医学, 2019, 30(10): 881-884.
ZHU Chunhong, ZHANG Fan, LEI Lianhui, SHI Bin, and YANG Yang. Occurrence and risk factors of hyperhomocysteine in railway workers. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(10): 881-884.
2019, Vol. 30 
