Immune-related ocular toxicities of PD-1/PD-L1 antibody versus chemotherapy for solid tumor: a meta-analysis
HOU Yanli1, WANG Yanling1, SU Qiang2, HU Jiexuan2, SONG Jie3
1. Department of Ophthalmology, 2. Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; 3. Department of Nephrology, Characteristic Medical Center of the Chinese People’s Armed Police Force,Tianjin 300162, China
Abstract：Objective To evaluate the immune-related ocular toxicities of PD-1/PD-L1 antibody versus chemotherapy in patients with solid tumors.Methods Such databases as PubMed and EMbase were searched as of December 2019. Related phase Ⅱ-Ⅳ controlled clinical trials were included. The ocular toxicities caused by PD-1/PD-L1 antibody and by chemotherapy were compared in solid tumor patients. Meta-analysis was performed using RevMan 5.3.Results There was no statistically significant difference in the risk of grade 1-5 and grade 3-5 adverse events between PD-1/PD-L1 antibody and chemotherapy[OR=1.34,95%CI(0.64-2.80);OR=1.20,95%CI(0.35-4.08)].The cases were the same with PD-1antibody[OR=1.20,95%CI(0.55-2.65);OR=1.00,95%CI(0.26-3.86)] and PD-L1 antibody [OR=2.82,95%CI(0.29-27.19);OR=2.85,95%CI(0.12-70.15)].Conclusions Our meta-analysis demonstrates that there is no significant difference in immune-related ocular toxicities between PD-1/PD-L1 antibody and chemotherapy.
侯艳丽, 王艳玲, 苏强, 胡杰轩, 宋洁. PD-1/PD-L1抗体与化学药物治疗眼部不良反应比较的Meta分析[J]. 武警医学, 2020, 31(8): 661-664.
HOU Yanli, WANG Yanling, SU Qiang, HU Jiexuan, SONG Jie. Immune-related ocular toxicities of PD-1/PD-L1 antibody versus chemotherapy for solid tumor: a meta-analysis. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(8): 661-664.
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2020, Vol. 31 
