Influence of ribapamide on curative effect and recurrence of helicobacter pylori positive peptic ulcer
PENG Le1, ZHANG Ya2, CHANG Haisheng1
1. The First Department of Internal Medicine, Beijing Municipal Corps Hospital of PAP, Beijing 100027,China; 2. Health Team of the First Brigade, Beijing Municipal Corps of PAP, Beijing 100006, China
Abstract：Objective To investigate the influence of ribapamide on the therapeutic effect and recurrence of helicobacter pylori (HP) - positive peptic ulcer. Methods Between October 2018 and September 2019, 110 patients with Helicobacter pylori positive peptic ulcer admitted to Beijing Municipal Corps Hospital of PAP were selected as the subjects. Sixty-two of these patients were treated with conventional quadruple sterilization and included in the control group, while the rest were additionally treated with ribapamide and included in the study group. Both groups were treated for two consecutive weeks. After treatment, the HP eradication rate and the therapeutic effect were detected and compared between the two groups. After treatment, patients in both groups were followed up for a minimum of six months. The number of HP positive cases during follow-up and the HP recurrence rate of the two groups were calculated. The serum levels of IL-6, TNF-a and CRP and other inflammation factors, hematocrit, RBC aggregation index, plasma viscosity and erythrocyte sedimentation rate and other hemorheological indexes before treatment and two weeks after treatment were measured and compared between the two groups. The rate of adverse reactions or complications was also compared between the two groups. Results The effective rate and eradication rate of HP in the study group were 95.83% and 95.83% respectively, which were higher than 80.65% and 82.26% in the control group. The recurrence rate of HP in the study group was 10.87%, which was lower than 27.45% in the control group (P<0.05). After two weeks of treatment, the serum IL-6 value was (9.11±1.66)ng/L, TNF-α value(1.25±0.25)μg/L and CRP value was(3.55±1.06)mg/L in the study group, compared to(13.74±2.03)ng/L,(2.17±0.34)μg/L and(5.26±1.43)mg/L in the control group, so the difference was statistically significant (P<0.05). After two weeks of treatment, serum levels of IL-6, TNF-α and CRP, hematocrit, erythrocyte aggregation index, plasma viscosity and erythrocyte sedimentation rate of the two groups decreased (P<0.05). There was no significant difference in the rate of adverse reactions or complications between the two groups. Conclusions The efficacy and safety of rebamipide tablets combined with conventional quadruple sterilization in the treatment of Hp-positive peptic ulcer are satisfactory, which can improve hemorheology, alleviate inflammatory reactions and prevent Hp recurrence. This approach should be made accessible.
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2020, Vol. 31 
