Clinical characteristics and prognosis of acute lower respiratory tract infections caused by respiratory syncytial virus and rhinovirus infections in infants
LIANG Gaili, WANG Yanhua, WANG Xiaojian, ZHANG Qing
Department of Pediatrics, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin 300162, China
Abstract：Objective To investigate the clinical characteristics of acute lower respiratory tract infections caused by respiratory syncytial virus (RSV) and/or human rhinovirus (HRV) in infants. Methods Clinical data of 138 infantile patients with acute lower respiratory tract infection, who were admitted to Characteristic Medical Center of Chinese People's Armed Police Force from January 2012 to December 2017, were divided into three groups: simple RSV group (84 cases), simple HRV group(20 cases), and coinfection group of RSV and HRV(84 cases). Clinical characteristics of the three groups were compared, and associations between respiratory viral infections, recurrent wheeze and asthma at aged 6-8 were analyzed. Results The infants with simple RSV infection was the youngest [(5.64±2.16) months, the proportion of respiratory failure was the highest (25.00%), the demand for oxygen was the highest (25.00%),and the difference was statistically significant (P<0.05). At the last follow-up visit, the rates of recurrent wheezing in RSV infection group, HRV infection group and RSV and HRV coinfection group were 39.29%, 20.00% and 35.29% respectively, and the rates of asthma were 7.14%, 10.00% and 11.76% respectively, with no significant difference (P>0.05). In the simple RSV group, the proportion of recurrent wheezing during the age of 6~8 years with family history of asthma (87.50%) was higher than that those without family history (23.08%) and the difference was statistically significant (P<0.001). Conclusion Infants with simple RSV infection are characterized by a higher proportion of respiratory failure, and infants with a family history of asthma are more likely to suffer from recurrent wheeze at the age of 6-8 years.
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