Abstract：Objective To understand the status of liver function of officers and soldiers stationed on plateau and analyze its correlation with altitude. Methods Five hundred and seventy-five liver function reports were randomly selected from the physical examination reports of officers and soldiers stationed in Aba prefecture, Sichuan Province. According to the altitude, they were divided into three groups: 144 cases in the < 2000 m group, 192 cases in the 2000-3000 m group and 239 cases in the >3000 m group. The liver function indicators studied included total bilirubin, indirect bilirubin, direct bilirubin, total protein, albumin, globulin, white globulin ratio, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, γ-Glutamyl transpeptidase and total bile acids. If any liver function indicator exceeded its normal range, it was judged as abnormal liver function. Results Of all the study objects, 198 cases (34.4%) had abnormal liver function, and the numbers of abnormal serum bilirubin, abnormal serum protein, abnormal serum transaminase and elevated total bile acid were 140 cases (24.3%) , 32 cases (5.6%) , 70 cases (12.2%) , and 15 cases (2.6%) respectively. The grouping study showed that the incidences of abnormalities of total bilirubin, indirect bilirubin, total bile acids, alanine aminotransferase, γ-Glutamyltranspeptidase, alkaline phosphatase, total protein, albumin and leukocyte ratio in >3000 m group were significantly higher than that in< 2000 m group and 2000-3000 m group (P<0.05), however, there was no significant difference between < 2000 m group and 2000-3000 m group (P>0.05). There was no significant difference in the incidence of abnormalities of direct bilirubin, aspartate aminotransferase and globulin among the three groups (P>0.05). Conclusions Abnormal liver function is common in officers and soldiers stationed at high altitude, and mainly manifested as the abnormalities of indirect bilirubin, total bilirubin and alanine aminotransferase. The damage of liver function is positively correlated with altitude, and mainly occurs in plateau area above 3000 meters, which needs to be paid special attention to.
曾仁攀, 王丹玲, 钱平. 高原驻训官兵肝功能损害状况及其与海拔高度的相关性[J]. 武警医学, 2023, 34(4): 291-294.
ZENG Renpan, WANG Danling, QIAN Ping. Liver function impairment of officers and soldiers stationed on plateau and its correlation with altitude. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(4): 291-294.
Xu C, Zhu H, Nakatsuka T, et al. Sampling strategy and climatic implication of tree-ring cellulose oxygen isotopes of hippophae tibetana and Abies georgei on the southeastern Tibetan Plateau[J]. Int J Biometeorol,2019, 63(5):679-686.
[2]
Pham K, Parikh K, Heinrich E C. Hypoxia and inflammation: insights from high-altitude physiology[J]. Front Physiol,2021,12:676782.
Bebic Z, Brooks Peterson M, Polaner D M. Respiratory physiology at high altitude and considerations for pediatric patients[J]. Paediatr Anaesth,2022,32(2):118-125.
Xin W, Xiaoli N, Shanguang Z, et al. Influence of exposure at different altitudes on the executive function of plateau soldiers-evidence from ERPs and neural oscillations[J]. Front Physiol,2021, 12:632058.
Toktogulova N, Tuhvatshin R R b. Features of the course of non-alcoholic fatty liver disease in experimental animals at high altitudes[J]. OA Maced J Med Sci,2021, 9:1092-1096.
[10]
Yeh Y C, Chen C C, Lin S H, et al. Case report: severe rhabdomyolysis and acute liver injury in a high-altitude mountain climber[J]. Front Med,2022, 9:917355.
2023, Vol. 34 
