Analysis of venous thromboembolism and related factors in inpatients with esophageal cancer
LI Hua1, LIANG Yan2, BIAN Chenfeng3
1. The Third Medical Center of PLA General Hospital, Beijing 100039,China; 2. Medical Security Centre of PLA General Hospital, Beijing 100039,China; 3. Radiotherapy Department, People’s Hospital of Dingzhou City, Dingzhou 073000, China
Abstract：Objective To investigate the incidence and risk factors of venous thromboembolism in hospitalized patients with esophageal cancer. Methods Clinical data of 466 patients with esophageal cancer treated in the Third Medical Center of PLA General Hospital from January 2020 to January 2023 were retrospectively analyzed, including general data (age, sex, body mass index, past history) and laboratory parameters (D-dimer, fibrinogen, albumin, serum homocysteine, and platelet). Venous color Doppler ultrasound was performed for all patients after admission, and CT pulmonary angiography was performed for patients with pulmonary symptoms to screen the incidence of venous thromboembolism. According to the occurrence of venous thromboembolism, they were divided into venous thromboembolism group (VTE group) and control group. Logistic multivariate regression analysis was used to summarize the related factors affecting the occurrence of venous thromboembolism and then the intervention strategies were discussed. Results Among 466 cases, venous thromboembolism occurred in 43 cases (9.2%). There were 6 cases (13.9%) of venous thrombosis in upper extremity.There were 35 cases (81.4%) of venous thrombosis in lower extremity and 2 cases (4.7%) of pulmonary venous thrombosis. Univariate analysis showed that the levels of age, serum D-dimer, fibrinogen, serum homocysteine (HCY) and platelet in the venous thromboembolism group were significantly higher than those in the control group, and the differences were statistically significant (P<0.05). Multivariate unconditional Logistic regression analysis showed that age, serum D-dimer level, fibrinogen and HCY were the risk factors for venous thrombosis (P<0.05). Conclusions The incidence of venous thromboembolism in hospitalized patients with esophageal cancer is high, most of the patients are asymptomatic and lower limb venous thrombosis is common. Age, serum D-dimer level, fibrinogen, and serum HCY are independent risk factors for venous thromboembolism in patients with esophageal cancer.
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2023, Vol. 34 
