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| Clinicopathological features of primary hepatic sarcoma |
| SUN Lu, SHI Huaiyin，and WEI Lixin. |
| Department of Pathology, General Hospital of People's Liberation Army, Beijing 100853, China |
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Abstract Objective To investigate the clinicopathological features and differential diagnosis of primary hepatic angiosarcoma (PHA). Methods Eleven cases of PHA were investigated at the light microscopic level and were studied by immunohistochemical techniques. Results Macroscopically, tumors showed diffuse, multi-nodular or single nodular patterns. Heamorrhage were observed. Microscopically, the tumor composed of endothelial cells which formed the irregular vessels or cavernous vascular space. Tumor cells were spindle-shaped or epithelioid with atypical nuclei. Multinucleated cells and prominent mitosis were seen in some areas. Immunohistochemical staining showed expression of Vimentin，CD31 and CD34 in all cases. Some cases had F-VⅢ associated antigen expression. None of the cases had Desmin, CD117, AFP or CK expression. Conclusions PHA is a rare malignant heamangioendothelial tumor. Its histological and immohistochemical features are necessary for the confirmation of diagnosis.
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Received: 28 December 2011
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Corresponding Authors:
韦立新，Email: weilx301@263.net
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| [1] |
. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(2): 169-172. |
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