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| Correlation between Sox2 expression and clinicopathological factors and prognosis in patients with breast carcinoma |
| YANG Guang, ZENG Xianyang, YE Shengquan, MU Xiaoqian, and YU Lan. |
| Liaoning Provincial Corps Hospital, Chinese People's Armed Police Forces, Shenyang 110034, China |
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Abstract Objective To investigate the correlation between Sox2 expression and clinicopathological factors and prognosis in patients with breast carcinoma. Methods Immunnohistochemistry was used to analyze the Sox2 expression in 138 cases of breast carcinoma and adjacent normal breast tissues. The relationship between Sox2 expression and clinicopathological factors was analyzed using Chi-square test. Survival curves were generated according to the Kaplan-Meier method. Results The difference in Sox2 expression between breast carcinoma and adjacent normal breast tissues was statistically significant ( P ＜0.01). The Sox2 expression was significantly correlated with histological grading（ P =0.015）, maxillary lymph node matastasis（ P =0.010）, TNM staging（ P =0.038），HER-2 positive（ P =0.031）and lower 5-year survival（ P =0.018）, rather than with tumor size, age of the patients or the state of estrogen receptor and progesterone receptor. Conclusions The high expression of Sox2 may be involved in the occurrence and development of breast carcinoma. The expression of Sox2 is not only associated with clinicopathological factors in breast carcinoma, but is likely to be a potential therapeutic target and a valuable prognostic indicator in breast carcinoma progression.
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Received: 07 February 2012
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