|
|
|
| Effect of combined leflunomide and cozaar therapy on IgA nephropathy |
| ZHANG Jianrong,ZHANG Chengying,GENG Yanqiu,and DING Tao. |
| Department of Nephrology,General Hospital of Chinese People’s Armed Police Forces,Beijing 100039,China |
|
|
|
|
Abstract Objective To study the effects of combined leflunomide and cozaar therapy on IgA nephropathy. Methods Forty patients with IgA nephropathy diagnosed by renal biopsy were randomly divided into two groups: cozaar (100 mg/d) treated group and leflunomide(20mg/d) plus cozaar treated group. The changes in proteinuria and serum creatinine were observed. Results After 1 month treatment by the two methods, the level of proteinuria decreased significantly ［(0.92±0.53) vs (1.28±0.99)］（P <0.05）in all.After 3 and 6 months of treatment , the level of proteinuria in combined leflunomide and cozaar therapy group was lower than that in cozaar therapy group（P<0.05）. Conclusions Combined leflunomide and cozaar therapy reduces 24 h urine proteinuria and protects renal function in patients with IgA nephropathy.
|
|
Received: 18 February 2012
|
|
|
|
|
|
| [1] |
. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(8): 833-834. |
|
|
|
|
2012, Vol. 23 
