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| Analysis of clinical features of 62 cases of skeletal fluorosis of and a comparison with 54 cases of ankylosing spondylitis |
| WANG Lan1,ZHAO Yanghui1,SU Jing1,TIAN Yuanyuan1,ZHANG Yifang1,LI Xia1,and ZHANG Liyun2. |
| 1. Department of Rheumatism Immunity,Shanxi Provincial Corps Hospital,Chinese People’s Armed Police Forces,Taiyuan 030006,China; 2. Department of Rheumatism Immunity,The Big Hospital of Shanxi,Taiyuan 030006,China |
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Abstract Objective To explore the differential diagnosis between skeletal fluorosis and ankylosing spondylitis. Methods 62 patients of skeletal fluorosis provided by a specialized hospital in Shanxi province and 54 AS patients admitted to Shanxi Provincial Corps Hospital from August 2009 to March 2010 were retrospectively analyzed. Results The age of onset（42.9±6.66） and number of peripheral joint pain (≥3)in skeletal fluorosis group were above those in AS group, and the difference was statistically significant（P <0.01）. The rate of deterioration after exercise( 83.9%,52 cases）was higher than that in AS group( 5.56%, 3 cases)（P<0.01）. The positive rate of HLA-B27 in skeletal fluorosis group (3.2% , 2 cases) was lower than that in AS group( 90.7% ,49 cases)（P<0.01）. The rate of limb bone lesions (100%, 62 cases) , peripheral joint disease（90.3%, 56cases） and interosseous membrane calcification（27.4%, 17 cases）was higher than in AS group（P<0.01）. The rate of spinal slub amyloidosis（61.3%, 38 cases）was higher than that in AS group (22.2%, 12cases)（P<0.05）. The rate of bone destruction in skeletal fluorosis group（0%,0 cases）was lower than that in AS group(29.6%,16 cases) (P<0.01). Conclusions Correct diagnosis should be made based on epidemiology、clinical manifestations、HLA-B27 test and imaging manifestations between skeletal fluorosis and ankylosing spondylitis.
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Received: 05 March 2012
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2012, Vol. 23 
