脑淀粉样血管病脑病理及其模型的研究进展

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[6]	陈平有,陈学强,杜恩甫,等. MRI在脑血管淀粉样变脑出血诊断中的应用[J]. 实用放射学杂志, 2011, 27(12):1807-1810.
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[7]	Masters C L, Simms G, Weinman N A, et al. Amyloid plaque core protein in Alzheimer disease and Down syndrome [J]. Proc Natl Acad Sci USA, 1985, 82(12): 4245-4248.
[13]	Iwata N, Tsubuki S, Takaki Y, et al. Metabolic regulation of brain Aβ by neprilysin[J]. Scienc, 2001, 292: 1550-1552.
[8]	McCarron M O, Nicoll J A, Love S, et al. Surgical intervention, biopsy and APOE genotype in cerebral amyloid angiopathy 2 related haemorrhage [J]. Br J Neurosurg, 1999, 13: 462-465.
[14]	Mouri A, Zou L B, Iwata N, et al. Inhibition of neprilysin by thiorphan (i.c.v) causes an accumulation of amyloid and impairment of learning and memory[J]. Behav Br Res, 2006, 168: 83-91.
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[9]	Maat-Schieman M, Roos R, Van Duinen S. Hereditary cerebral hemorrhage with amyloidosis-Dutch type[J]. Neuropathology, 2005, 25(4): 288-297.
[10]	Attems J. Sporadic cerebral amyloid angiopathy: pathology,clinical implications, and possible pathomechanisms [J]. Acta Neuropathol(Berl), 2005, 110(4): 345-359.
[16]	Nobuhisa I, Tsubuki S. Identification of the major Aβ 1-42-degrading catabolic pathway in brain parenchyma: Su-ppression leads to biochemical and pathological deposition [J]. Natrue Med, 2000, 6: 143-150.
[11]	Rosand J, Muzikansky A, Kumar A, et al. Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy [J]. Ann Neurol, 2005, 58(3): 459-462.
[17]	Nobuhisa I, Mizukami H, Sirotani K, et al. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid -β peptide in mouse brain [J]. J Neurosci, 2004, 24(4): 991-998.
[12]	Izumihara A, Suzuki M, Ishihara T. Recurrence and extension of lobar hemorrhage related to cerebral amyloid ngilpathy:multivariate analysis of clinical risk factors[J]. Surg Neurol, 2005, 64(2): 160-164.
[18]	樊东升. 脑淀粉样血管病相关性出血[J]. 国外医学脑血管疾病分册, 2001, 9(4): 234-236.
[19]	许丹,杨春慧, 王鲁宁, 等. 老年人脑淀粉样血管病的临床及病理研究[J]. 中华内科杂志, 2003, 42(8): 541-543.
[13]	Iwata N, Tsubuki S, Takaki Y, et al. Metabolic regulation of brain Aβ by neprilysin[J]. Scienc, 2001, 292: 1550-1552.
[14]	Mouri A, Zou L B, Iwata N, et al. Inhibition of neprilysin by thiorphan (i.c.v) causes an accumulation of amyloid and impairment of learning and memory[J]. Behav Br Res, 2006, 168: 83-91.
[20]	殷小平,张苏明,郑美蓉, 等. 血管淀粉样变相关脑出血的初步研究[J]. 中华医学杂志,2005,85(2):120-121.
[15]	Iwata N, Takaki Y, Fukami S, et al. Region-specific reduction of A β degrading endopeptidase, neprilysin, in mouse hippocampus upon aging[J]. J Neurosci Res, 2002,70: 493-500.
[21]	Huang J, Guan H, Booze R M, et al. Estrogen regulates neprilysin activity in rat brain [J]. Neurosci Lett, 2004, 367(1): 85-87.
[16]	Nobuhisa I, Tsubuki S. Identification of the major Aβ 1-42-degrading catabolic pathway in brain parenchyma: Su-ppression leads to biochemical and pathological deposition [J]. Natrue Med, 2000, 6: 143-150.
[22]	Shirotani K, Tsubuki S, Iwata N, et al. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidlyand drriciently among thiorphan-and phosphoramidon-sensitive endopeptidases[J]. J Biol Chem, 2001, 276(24): 21895-21901.
[17]	Nobuhisa I, Mizukami H, Sirotani K, et al. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid -β peptide in mouse brain [J]. J Neurosci, 2004, 24(4): 991-998.
[23]	Marr R A, Rockenstein E, Mukherjee A, et al. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice[J]. J Neurosci, 2003, 23(6): 1992-1996.
[18]	樊东升. 脑淀粉样血管病相关性出血[J]. 国外医学脑血管疾病分册, 2001, 9(4): 234-236.
[24]	Tian J, Shi J, Bailey K, et al. Relationships between arteriosclerosis, cerebral amyloid angiopathy and myelin loss from cerebral cortical white matter in Alzheimer’s disease [J]. Neuropathol Appl Neurobiol, 2004, 30(1): 46-56.
[19]	许丹,杨春慧, 王鲁宁, 等. 老年人脑淀粉样血管病的临床及病理研究[J]. 中华内科杂志, 2003, 42(8): 541-543.
[25]	Hauss-Wegrzyniak B, Wenk G L. Beta-amyloid deposition in the brains of rats chronically infused with thiorphan or lipopolysaccharide: the role of ascorbic acid in the vehicle [J]. Neurosci Lett, 2002, 322(2): 75-78.
[20]	殷小平,张苏明,郑美蓉, 等. 血管淀粉样变相关脑出血的初步研究[J]. 中华医学杂志,2005,85(2):120-121.
[21]	Huang J, Guan H, Booze R M, et al. Estrogen regulates neprilysin activity in rat brain [J]. Neurosci Lett, 2004, 367(1): 85-87.
[22]	Shirotani K, Tsubuki S, Iwata N, et al. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidlyand drriciently among thiorphan-and phosphoramidon-sensitive endopeptidases[J]. J Biol Chem, 2001, 276(24): 21895-21901.
[23]	Marr R A, Rockenstein E, Mukherjee A, et al. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice[J]. J Neurosci, 2003, 23(6): 1992-1996.
[24]	Tian J, Shi J, Bailey K, et al. Relationships between arteriosclerosis, cerebral amyloid angiopathy and myelin loss from cerebral cortical white matter in Alzheimer’s disease [J]. Neuropathol Appl Neurobiol, 2004, 30(1): 46-56.
[25]	Hauss-Wegrzyniak B, Wenk G L. Beta-amyloid deposition in the brains of rats chronically infused with thiorphan or lipopolysaccharide: the role of ascorbic acid in the vehicle [J]. Neurosci Lett, 2002, 322(2): 75-78.