冠心病不同分支病变对血清新喋呤、同型半胱氨酸及基质金属蛋白酶的影响

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Abstract Objective To investigate the effects of serum neopterin and homocysteine levels on substrate metals protease in patients with coronary heart disease in different branches. Methods 148 coronary heart disease patients were divided into single lesion group and double branch lesion group, multivessel lesions group, 58, 53, and 37 cases, respectively. Blood was sampled to detect Hcy, Np, MMP-2, MMP-9 and TIMP-2 levels. Results Hcy in duble lesion group was significantly higher than in single lesion (P<0.05), Np [(12.45±3.09)nmol/L] and Hcy [(23.71±4.57) μmol/L] in multilesion group showed significant increase than in the groups A and B (P<0.05). MMP-2[(49.83±7.64)ng/L], and MMP-9[(194.81±17.58)ng/L] in double lesion group were significantly higher than in single lesion group (P<0.05), TIMP-2 [(283.70±23.45)ng/L] in double lesion group significantly decreased (P<0.05). MMP-2 [(63.42±8.59)ng/L], MMP-9 [(249.73±24.16) ng/L] and TIMP-2 [(205.61±17.32)ng/L] in multilesion group were significantly different from the single and double lesion groups (P<0.05). Np and MMP-9 showed significant positive correlation (P<0.05), and TIMP-2 showed significantly negative correlation (P<0.05), Hcy and MMP-2 and MMP-9 showed significantly positive correlation (P<0.05), and TIMP-2 showd significantly negative correlation (P<0.05). Conclusions Np and Hcy are closely related to the field of coronary heart disease, which are closely related to MMPs indicating the progression of coronary atherosclerosis.

Key words： coronary heart disease neopterin homocysteine matrix metalloproteinases

Received: 27 August 2014

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	XU Xia
	BAI Xiao
	JIA Xiaowei

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XU Xia,BAI Xiao,JIA Xiaowei. Effects of serum neopterin and homocysteine levels on substrate metals protease in patients with coronary heart disease in different branches[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(3): 256-258.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I3/256

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