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| Curative effect of low dose olanzapine combined with duloxetine in treatment of depression with pain symptoms |
| ZHOU Lei1,MA Rui2, ZHANG Ying1,CAO Lei1,LIU Baichuan3, LI Dehui1 |
1. Department of Mental Health,3. Medical Department,Jilin Provincal Corps Hospital,Chinese People’s Armed Police Forces,Changchun 130052,China;
2. Psychology Department,the Sixth Hospital of Changchun City,Changchun 130052,China |
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Abstract Objective To study the curative effect of low dose olanzapine combined with duloxetine in the treatment of depression with pain symptoms. Methods 70 patients with pain symptoms of depression were randomly divided into study group (35 cases, duloxetine combined with small dose olanzapine) and control group (35 cases, duloxetine therapy), for a course of six weeks. Before treatment and after treatment, Hamilton depression scale (HAMD) and the Medical Outcomes Study Pain Measurement scale (MOSPM) were used to assess curative effect. TESS evaluation of drug side effects was performed. Results In the two groups, HAMD scores at the end of 2 week began to exhibit difference (P<0.05). At the ends of 4 weeks and 6 weeks, scores were significantly different between the two groups (P<0.01). In the two groups, MOSPM score points, at the end of 4 weeks, began to be statistically significant (P<0.05), at the end of 6 weeks, in the two groups, MOSPM score had significant difference (P<0.01). In the two groups, adverse reaction scale (TESS) score had no significant difference (P>0.05). The study group, at the end of 6 week, showed the efficiency of 71.43%, effective rate of 88.57%. The control group, at the end of 6 weeks showed efficiency, of 62.85%, effective rate of 85.71%. Compare is on of curative effect botween the two groups exhibited statistically significant difference (P<0.05). Conclusions Duloxetine combined with low dose olanzapine for treatment of depression with pain symptoms is superior to the single drug.
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Received: 17 April 2014
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| [1] |
李学灵,屈建新,耿寒松,等. 度洛西汀联合小剂量奥氮平对抑郁症患者的治疗作用[J].临床精神医学杂志,2013,23(1):35-36.
|
| [2] |
肖 云,何 茹. 度洛西汀对躯体化障碍患者抑郁症状疗效及生活质量的研究[J].实用药物与临床, 2008,11(3):135-136.
|
| [3] |
Cartlehner G,Gaynes B N,Hansen R A,et al. 比较第二代抗抑郁药物的益处与危害[J].精神相关疾病论坛,2009,(2):20.
|
| [4] |
Stahl S M.The psyehopharmacology of painful physical syruptoms in depression[J]. J Clin Psychiatry,2002,63(5):382-383.
|
| [5] |
王刚平,颉 瑞. 度洛西汀与西酞普兰治疗伴疼痛症状抑郁症的对照研究[J].国际精神病学杂志,2013,40(1):4-6.
|
| [6] |
俞东山,葛茂宏.精神科合理用药手册[M]. 2版.南京:江苏科学技术出版社,2011:29.
|
| [7] |
郭文斌,孙 华,锰 钢,等. 合并小剂量奥氮平治疗躯体形式障碍的对照研究[J].神经疾病与精神卫生,2010,16(5):448-450.
|
| [8] |
王彬彬,赵志欣. 奥氮平联合文拉法辛缓释片治疗躯体形式障碍疗效观察[J]. 中国健康心理学杂志,2012,20(8):968-969.
|
| [9] |
张 颖,曹 雷,周 磊,等. 选择性5-羟色胺再摄取抑制剂联合奥氮平治疗难治性抑郁症疗效观察[J].武警医学院学报,2011,20(11):897-898.
|
| [10] |
方建忠,梅其一,杨小男,等. 非典型抗精神病药对难治性抑郁症的治疗作用[J].临床精神医学杂志,2007,17(1):36-37.
|
| [11] |
白晓光,刘翠美. 安非他酮联合奥氮平与安非他酮单用治疗抑郁症的疗效比较[J].中国健康心理学杂志,2012,20(10):1467-1468.
|
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2015, Vol. 26 
