氨甲环酸对减少同期双侧全髋关节置换术围术期出血的疗效

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Abstract Objective To study the efficacy and safety of tranexamic acid for simultaneous bilateral total hip arthroplasty. Methods From 2013 October to 2015 August, forty-eight simultaneous bilateral total hip arthroplasty(THA) were retrospectively analyzed. Combination of systemic and local application of tranexamic acid were given in twenty-four cases. No tranexamic acid was used in twenty-four cases as control group. Drain volume, total blood loss, hidden blood loss, transfusion rate and transfusion volume,hemoglobin level, platelet count, and symptomatic venous thromboembolism were recorded and compared. Results Drain volume, total blood loss, hidden blood loss, transfusion rate, transfusion volume in tranexamic acid group and control group were 355.4 ml and 574.4 ml, 1894.1 ml and 2959.3 ml , 1538.7 ml and 2384.9 ml, 50.0% and 100.0%, 360 ml and 1340 ml, respectively, with significant difference(P<0.05). There was no difference in intraoperative blood loss. No symptomatic venous thrombombolism was identified in either group. Conclusions Combination of systemic and local application of tranexamic acid significantly reduces blood loss for bilateral simultaneous total hip arthroplasty while does not increase the risk of venous thromboembolism.

Key words： tranexamic acid total hip arthroplasty avascular necrosis of femoral head hidden blood loss deep vein thrombosis

Received: 22 September 2015

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	GU Jianming
	LI Wei
	DU Hui
	SHAO Hongyi
	ZHOU Yixin

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GU Jianming,LI Wei,DU Hui等. Combination of intravenous and local application of tranexamic acid significantly reduce blood loss in simultaneous bilateral total hip arthroplasty[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(2): 119-122.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2016/V27/I2/119

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