光学相干断层扫描与3.0T MRI、超声法测量兔膝关节软骨厚度的比较

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Abstract Objective To verify the feasibility of optical coherence tomography(OCT) for thickness measurement of rabbit knee joint cartilage as a non-invasive measurement method via comparing with 3.0 T MRI and ultrasonic pachymetry. Methods 40 standardized culturea, adult and male New Zealand white rabbits were recruited for this study(80 knees). Ultrafine probe was used to mark measurement point. Using OCT, 3.0 T MRI and ultrasonic techniques, cartilage thickness data were obtained at the same point,respectively. The difference between OCT and the other two methods was compared. Results The numerical results of OCT, 3.0 T MRI, ultrasonic pachymetry measurement method of cartilage thickness were(0.31±0.03)mm,(0.30±0.05)mm,(0.33±0.06)mm,respectively, without statistically significant difference (OCT- ultrasonic t=1.995,P=0.051,OCT-MRI t=1.955,P=0.054). And the time required were(2.5±0.3)min、(6.3±0.7)min、(3.3±0.6)min, respectively. The accuracy of the three measuring methods were 0.001 mm, 0.01 mm and 0.01 mm. Conclusions Compared with 3.0 TMRI and ultrasonic pachymetry, OCT measurement of rabbit knee joint cartilage thickness has the advantages of precision, time-saving, good repeatability, low cost ,and human error small, worthy of animal experimental practice.

Key words： optical coherence tomography MRI ultrasonic pachymetry cartilage thickness animal experiment

Received: 25 December 2015

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	Articles by authors
	ZHANG Jiating
	GUO jing
	WU Mei
	ZHONG Xin
	GAO Yongyan
	LIU Chuan
	and ZHANG Zhongwen

Cite this article:

ZHANG Jiating,GUO jing,WU Mei等. Comparison of optical coherence tomography with 3.0 TMRI and ultrasonic pachymetry for thickness measurement of rabbit knee joint cartilage[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(5): 472-475.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2016/V27/I5/472

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