|
|
|
| The consumption of antibiotics and the resistant situation of Gram negative bacteria in a BeijingTertiaryHospital |
| WANG Xiangdang1, LIU Xiaojun2, and LU Yanxia2 |
| 1.Medical Procurement Center, 2. Department of Pharmacy, General Hospital of Chinese People’s Armed Police Force, Beijing 100039, China |
|
|
|
|
Abstract Objective To analyze the consumption of antibiotics and resistant situation of antimicrobics isolated during January 2013- December 2015 from a Beijing Tertiary Hospital, which could be helpful for the clinical doctors to use antibacterial agents rationally and control the growth of bacterial resistance.Methods The defined daily dose (DDD) method were used to survey the hospital bacteria resistant situation and the antibacterial consumption for inpatients from January 2013 to December 2015. The type of antibacterial agents, the stock-out amount and the amount of money were collected and analyzed retrospectively by the hospital computer management software.Results In the past three years,the consumption of penicillin, cephalosporins, aminoglycoside, and fluoroquinolones showed varying degrees of decline, but, the usage of carbapenems antibiotics and cephalosporin+enzyme inhibitor has been increased; The drug resistance rate of four common gram-negative bacteria for amoxicillin was the highest with more than 90% and for cefuroxime above 60% and for cefoperazonesulbactam with the lowest resistant rate, which was sensitive to four common gram negative bacilli. In addition to Bauman Acinetobacter, other three kinds of bacteria.has high sensitivity to carbapenems, Amikacin, cefoxitin, ceftazidime and cefepime.Conclusions The widespread use or irrational use of antibacterial drugs can accelerate the rate of bacterial resistance, while the rational and standardized use of antimicrobial agents can help delay the development of bacterial resistance.Drug resistance of clinical isolated bacteria to antibiotics in our hospital is still not optimistic, in order to reduce hospital infection, we should strengthen the management of antimicrobial drug use.
|
|
Received: 16 March 2017
|
|
|
|
|
|
| [1] |
Cesar A, Barbara E. Antibiotic-resistant bugs in the 21st century-a clinical super-challenge[J]. N Engl J Med, 2009, 360(5):439-443.
|
| [2] |
Brad S, John G, David N. The future of antibiotics and resistance[J]. N Engl J Med, 2013, 368(4):299-302.
|
| [3] |
Thomas J, Sandora, Donald A. Preventing Lethal Hospital outbreaks of antibiotic-resistant bacteria[J]. N Engl J Med, 2012, 367(23):2168-2170.
|
| [4] |
俞云松.正确认识产新德里金属β内酰胺酶-1的超级细菌[J].中华检验医学杂志, 2010,33(6):1109-1111.
|
| [5] |
CLSI. Performance standards for antimicrobial susceptibility testing: twenty-second informational supplement [M]. 2015: M100-S25.
|
| [6] |
WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC Classification and DDD Assignment [M].13th ed.Norway:Norwegian InstPublHlth, 2009.
|
| [7] |
陈新谦,金有豫,汤光.新编药物学[M]. 17版.北京人民卫生出版社,2011: 34-105.
|
| [1] |
. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(11): 1163-1165. |
|
|
|
|
2017, Vol. 28 
