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| Comparison of clinical efficacy of praziquantel of different doses in the treatment of chronic schistosomiasis |
| LI Chaoqun1, LUO Dan2, YANG Xin3, MA Ranping4, ZHANG Baoxin5, JIAN Ming6 |
1.Department of Pharmacy,2.Department of Clinical Laboratory,5. Department of Medical Affairs,6. Hospital Office,Hunan Provincial corps Hospital of Chinese People’s Armed Police Force,Changsha 410006,China;
3. Chenzhou Hospital, Chinese People’s Armed Police Force,Chenzhou 423000,China;4. Department of Hygiene,Logistic University of Chinese People’s Armed Police Force,Tianjin 300162,China |
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Abstract Objective To explore the effect of doses on the efficacy of praziquantel in the treatment of chronic schistosomiasis.Methods Ninety patients treated at Hunan Corps Hospital of the Armed Police were randomly divided into two groups. In the low-dose group, 45 patients were given praziquantel at a dose of 40 mg/kg, while in the conventional-dose group the 45 patients were given a conventional dose of 60 mg/kg. Both groups took the drug two or three times a day for two days, two groups were compared.Results The efficacy of low-dose group and the conventional-dose group was roughly equal.The efficacy, usage of liver-protecting drugs, and adverse reaction rates were not significantly different between the two groups (P>0.05).Conclusions Low-dose praziquantel is as effective as conventional-dose praziquantel and can reduce the usage of praziquantel.
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Received: 30 July 2018
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| [1] |
葛华阶, 白定华, 夏晓玲,等. 软肝丸治疗血吸虫病肝纤维化的效果[J]. 中国血吸虫病防治杂志, 2014, 26(2):197
|
| [2] |
吴维铎, 沈光金, 王 勇,等. 低剂量吡喹酮治疗慢性日本血吸虫病218例效果观察[J]. 热带病与寄生虫学, 2001, 30(2):79-80.
|
| [3] |
李剑珉, 徐 军, 涂永红. 小剂量吡喹酮治疗慢性血吸虫病的疗效观察[J]. 南昌大学学报(医学版), 2011, 51(6):33-33.
|
| [4] |
Handing P, Desheng H, Ketai W. Approach to surveillance and consolidation during past 15 years after elimination of schistosomiasis in Shanghai[J]. Acta Trop, 2002, 82(2):301-303.
|
| [5] |
张利娟, 徐志敏, 钱颖骏,等. 2016年全国血吸虫病疫情通报[J]. 中国血吸虫病防治杂志, 2017,29(6):669-677.
|
| [6] |
Salvadorrecatalà V, Greenberg R M. Calcium channels of schistosomes: unresolved questions and unexpected answers[J]. Wiley Interdisciplinary Reviews Membrane Transport & Signalling, 2012, 1(1):85-93.
|
| [7] |
欧阳青兰. 吡喹酮治疗血吸虫病的疗效及不良反应分析[J]. 临床合理用药杂志, 2016, 9(26):50-51.
|
| [8] |
Cioli D, Pica-Mattoccia L. Praziquantel[J]. Parasitol Res, 2003, 90(1):S3-S9.
|
| [9] |
黄一心. 吡喹酮抗血吸虫作用机理的奥秘[J]. 中国血吸虫病防治杂志, 2010, 22(2):101-104.
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2018, Vol. 29 
