A型肉毒毒素联合氟尿嘧啶在瘢痕疙瘩手术治疗中的应用

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Abstract Objective To investigate the applicability of surgical excisions followed by injection of botulinum toxin type A and 5-fluorouracil for keloids.Methods Sixty-eight consecutive patients who underwent surgical excisions for keloids in the Department of Burn and Skin Surgery of Xijing Hospital between July 2015 to July 2017 were enrolled.Botulinum toxin type A and 5-fluorouracil were injected into the surgical wounds of 34 patients, while triamcinolone acetonide was injected into the surgical wounds of another 34 patients. The Scar Cosmesis Assessment and Rating(SCAR), Vancouver Scar Scale score, recurrence rates and patients’levels of satisfaction were compared between the two groups.Results In terms of SCAR[(7.46±1.26) vs (11.51±2.33)],Vancouver Scar Scale score[(6.31±4.16) vs (9.37±4.82)], recurrence rates(5.88% vs 23.53%) and patients’ levels of satisfaction[(9.17±0.82) vs (6.62±1.16)], the botulinum toxin type A and 5-fluorouracil treated group was superior to the triamcinolone acetonide treated group, and the difference was statistically significant(P＜0.05).Conclusions Botulinum toxin type A and 5-fluorouracil injections can reduce the incision scars after surgical excisions for keloids, improve the surgical effect, reduce recurrence rates, and leave patients more satisfied,so this approach is worthy of clinical application.

Key words： botulinum toxin type A keloid recurrence rates

Received: 10 August 2018

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	XU Zhigang
	CHEN Qiaohua
	HU Dahai
	HOU Hongyi

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XU Zhigang,CHEN Qiaohua,HU Dahai等. Applicability of surgical excisions followed by injection of botulinum toxin type A and 5-fluorouracil for keloids[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(3): 196-199.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I3/196

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