通心络对急性冠脉综合征患者PCI术后炎性反应及血管内皮功能的影响

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Abstract Objective To study the effects of Tongxinluo on inflammation, endothelial function and artery elasticity in patients with acute coronary syndrome (ACS).Methods One hundred and thirty-seven patients who were diagnosed with ACS and prepared for PCI between October 2017 and March 2018 were selected as the subjects. They were randomly divided into the Tongxinluo group (n=68) and control group (n=69). Levels of Angptl2, IL-18, and PAI-1 in plasma were measured using ELISA methodology after admission and during the 12-week follow-up. The brachial artery flow-mediated dilation (FMD) and C2 were also calculated at the same time points and compared between the two groups.Results After 12-week follow-up, the levels of serum Angptl2, IL-18, and PAI-1 in the Tongxinluo group were (27.61±8.55) ng/L, (75.66±10.22) pg/mL and (26.64±8.00) μg/L respectively, which were lower than (32.30±11.56) ng/L, (91.81±12.99) pg/mL and (30.92±6.64) μg/L in the control group (P<0.05). Patients in the Tongxinluo group had higher levels of FMD (8.99±1.12) and C2 (6.32±0.70) ml/mmHg×100 than those [(6.65±0.95;5.42±0.91) mL/mmHg×100] in the control group (P<0.05).Conclusions Tongxinluo capsules can reduce inflammation, restore the endothelial function and arterial elasticity in ACS patients.

Key words： acute coronary syndrome PCI inflammation endothelial function

Received: 20 November 2018

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	YANG Guanglei

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YANG Guanglei. Effect of Tongxinluo on inflammation, endothelial function and artery elasticity in patients with acute coronary syndrome[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(3): 233-236.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I3/233

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