| [1] |
Sakurai T, Kudo M, Fukuta N, et al. Involvement of angiotensin II and reactive oxygen species in pancreatic fibrosis[J]. Pancreatology, 2011, 11 (Suppl 2): 7-13.
|
| [2] |
Yadav D, Lowenfels A B. The epidemiology of pancreatitis and pancreatic cancer[J]. Gastroenterology, 2013, 144(6): 1252-1261.
|
| [3] |
Wang L W, Li Z S, Li S D, et al. Prevalence and clinical features of chronic pancreatitis in China: a retrospective multicenter analysis over 10 years[J]. Pancreas, 2009, 38(3): 248-254.
|
| [4] |
Omary M B, Lugea A, Lowe A W, et al. The pancreatic stellate cell: a star on the rise in pancreatic diseases[J]. J Clin Invest, 2007,117(1): 50-59.
|
| [5] |
Bynigeri R R, Jakkampudi A, Jangala R, et al. Pancreatic stellate cell: Pandora’s box for pancreatic disease biology[J]. World J Gastroenterol, 2017, 23(3): 382-405.
|
| [6] |
Apte M, Pirola R, Wilson J. The fibrosis of chronic pancreatitis: new insights into the role of pancreatic stellate cells[J]. Antioxid Redox Signal, 2011, 15(10): 2711-2722.
|
| [7] |
Erkan M, Adler G, Apte M V, et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research[J]. Gut, 2012, 61(2): 172-178.
|
| [8] |
Andoh A, Takaya H, Saotome T, et al. Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts[J]. Gastroenterology, 2000, 119(1): 211-219.
|
| [9] |
Ulmasov B, Neuschwander-Tetri B A, Lai J, et al. Inhibitors of Arg-Gly-Asp-Binding integrins reduce development of pancreatic fibrosis in mice[J]. Cell Mol Gastroenterol Hepatol, 2016, 2(4): 499-518.
|
| [10] |
Shimizu K. Pancreatic stellate cells: molecular mechanism of pancreatic fibrosis[J]. J Gastroenterol Hepatol, 2008, 23(Suppl 1): S119-S121.
|
| [11] |
王兴鹏, 龚自华. 胰腺星状细胞在大鼠胰腺纤维化形成中的作用[J]. 中华消化杂志, 2003, 23(8): 14-17.
|
| [12] |
Tahara H, Sato K, Yamazaki Y, et al. Transforming growth factor-α activates pancreatic stellate cells and may be involved in matrix metalloproteinase-1 upregulation[J]. Lab Invest, 2013, 93(6): 720-732.
|
| [13] |
Qian Z Y, Peng Q, Zhang Z W, et al. Roles of Smad3 and Smad7 in rat pancreatic stellate cells activated by transforming growth factor-beta 1[J]. Hepatobiliary Pancreat Dis Int, 2010, 9(5): 531-536.
|
| [14] |
Yoo B M, Yeo M, Oh T Y, et al. Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling[J]. Pancreas, 2005, 30(3): e71-e79.
|
| [15] |
Aoki H, Ohnishi H, Hama K, et al. Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells[J]. Am J Physiol Cell Physiol, 2006, 290(4): C1100-C1108.
|
| [16] |
Aoki H, Ohnishi H, Hama K, et al. Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated rat pancreatic stellate cells[J]. J Cell Biochem, 2006, 99(1): 221-228.
|
| [17] |
Shek F W, Benyon R C, Walker F M, et al. Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis[J]. Am J Pathol, 2002, 160(5): 1787-1798.
|
| [18] |
张 青, 王亚丽, 卢美丽, 等. TGFβ1刺激不同时间对胰腺腺泡细胞中ZNF580和EMT相关因子的影响[J]. 武警后勤学院学报(医学版), 2016, 25(12): 959-963.
|
| [19] |
Liu H, Yu K, Ma P, et al. Long noncoding RNA myocardial infarction-associated transcript regulated the pancreatic stellate cell activation to promote the fibrosis process of chronic pancreatitis[J]. J Cell Biochem, 2018 .
|
| [20] |
苏丽婷, 夏时海, 郑永青. 转化生长因子β1Ⅱ型受体在大鼠慢性胰腺炎中的表达及氧化苦参碱对其的影响[J]. 世界华人消化杂志, 2011, 19(2): 121-125.
|
| [21] |
王昱良, 郑永青, 夏时海, 等. 氧化苦参碱对慢性胰腺炎胰腺组织中Ⅰ型胶原及α-SMA的影响[J]. 世界华人消化杂志, 2010, 18(13): 1331-1336.
|
| [22] |
宗林飞. 基于JAK2/STAT3通路的氧化苦参碱抗胰腺纤维化机制研究. 见:夏时海, 向晓辉,主编. .
|
| [23] |
李嫚华, 陈 凯, 张 青, 等. 氧化苦参碱通过促进胰腺星状细胞株中Gli2表达发挥抗胰腺纤维化作用[J]. 中草药, 2018, 49(13): 3069-3073.
|
| [24] |
张 斌, 许 威, 李如月, 等. 氧化苦参碱抑制DBTC刺激的胰腺腺泡细胞中上皮间质转化相关蛋白及TβRⅡ和p-Smad2/3表达[J]. 遵义医学院学报, 2017, 40(5): 531-535.
|
| [25] |
Tsang S W, Zhang H, Lin C, et al. Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis[J]. PLoS One, 2013, 8(12): e82201.
|
| [26] |
Liu L, Zhu Y, Nu M, et al. Neuronal transforming growth factor beta signaling via SMAD3 contributes to pain in animal models of chronic pancreatitis[J]. Gastroenterology, 2018, 154(8): 2252-2265.e2.
|
| [27] |
田珍珍, 朱 杰, 王淑华, 等. 慢性胰腺炎患者胰腺和血清中TLR4信号通路关键因子的检测及其意义[J]. 吉林大学学报(医学版), 2013, 39(4): 763-767, 866.
|
| [28] |
Szabo G, Mandrekar P, Oak S, et al. Effect of ethanol on inflammatory responses. Implications for pancreatitis[J]. Pancreatology, 2007, 7(2-3): 115-123.
|
| [29] |
Vonlaufen A, Phillips P A, Xu Z, et al. Withdrawal of alcohol promotes regression while continued alcohol intake promotes persistence of LPS-induced pancreatic injury in alcohol-fed rats[J]. Gut, 2011, 60(2): 238-246.
|
| [30] |
Pan L F, Yu L, Wang L M, et al. The toll-like receptor 4 antagonist transforming growth factor-β-activated kinase(TAK)-242 attenuates taurocholate-induced oxidative stress through regulating mitochondrial function in mice pancreatic acinar cells [J]. J Surg Res, 2016, 206(2): 298-306.
|
| [31] |
Pan L F, Yu L, Wang L M, et al. The Toll-like receptor 4 antagonist TAK-242 protects against chronic pancreatitis in rats[J]. Mol Med Rep, 2017, 16(4): 3863-3868.
|
| [32] |
李如月, 向晓辉, 张 斌, 等. 氧化苦参碱通过胰腺星状细胞中miRNA-211-5p调节TLR4/NF-κB通路调控炎性反应[J]. 药物评价研究, 2018, 41(4): 540-546.
|
| [33] |
卢美丽, 陈 凯, 张 青, 等. 氧化苦参碱对脂多糖诱导的AR42J细胞MyD88/NF-κBp65信号通路的调节作用[J]. 武警后勤学院学报(医学版), 2017, 26(8): 645-648.
|
| [34] |
Lu M, Zhang Q, Chen K, et al. The regulatory effect of oxymatrine on the TLR4/MyD88/NF-κB signaling pathway in lipopolysaccharide-induced MS1 cells[J]. Phytomedicine, 2017, 36: 153-159.
|
| [35] |
Wang Y S, Li Y Y, Wang L H, et al. Tanshinone IIA attenuates chronic pancreatitis-induced pain in rats via downregulation of HMGB1 and TRL4 expression in the spinal cord[J]. Pain Physician, 2015, 18(4): E615-E628.
|
| [36] |
Komar H M, Serpa G, Kerscher C, et al. Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo [J]. Sci Rep, 2017, 7(1): 1787.
|
| [37] |
张 青, 李嫚华, 陈 凯, 等. Gli1基因沉默通过抑制JAK2/STAT3信号通路阻抑TGF-β1诱导胰腺星状细胞纤维化[J]. 武警后勤学院学报(医学版), 2017, 26(12): 1028-1033.
|
| [38] |
朱林佳. 大柴胡汤通过调控IL-6/STAT3信号通路对L-Arginine诱发CP胰腺纤维化的防治作用[D]. 西安:陕西中医药大学, 2016.
|
| [39] |
Gukovsky I, Gukovskaya A S. Impaired autophagy triggers chronic pancreatitis: lessons from pancreas-specific atg5 knockout mice[J]. Gastroenterology, 2015, 148(3): 501-505.
|
| [40] |
Diakopoulos K N, Lesina M, Wörmann S, et al. Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes [J]. Gastroenterology, 2015, 148(3): 626-638.e17.
|
| [41] |
Antonucci L, Fagman J B, Kim J Y, et al. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress[J]. Proc Natl Acad Sci U S A, 2015, 112(45): E6166-E6174.
|
| [42] |
Li N, Wu X, Holzer R G, et al. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice [J]. J Clin Invest, 2013, 123(5): 2231-2243.
|
| [43] |
Mareninova O A, Sendler M, Malla S R, et al. Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis[J]. Cell Mol Gastroenterol Hepatol, 2015, 1(6): 678-694.
|
| [44] |
Li C X, Cui L H, Zhuo Y Z, et al. Inhibiting autophagy promotes collagen degradation by regulating matrix metalloproteinases in pancreatic stellate cells[J]. Life Sci, 2018, 208: 276-283.
|
| [45] |
Xu M, Wang G, Zhou H, et al. TGF-β1-miR-200a-PTEN induces epithelial-mesenchymal transition and fibrosis of pancreatic stellate cells[J]. Mol Cell Biochem, 2017, 431(1-2): 161-168.
|
| [46] |
Li L, Wang G, Hu J S, et al. RB1CC1-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis[J]. Cell Death Dis, 2018, 9(10): 952.
|
| [47] |
Cui L, Li C, Gao G, et al. FTY720 inhibits the activation of pancreatic stellate cells by promoting apoptosis and suppressing autophagy via the AMPK/mTOR pathway[J]. Life Sci, 2019, 217: 243-250.
|
| [48] |
Cui L H, Li C X, Zhuo Y Z, et al. Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway[J]. Chem Biol Interact, 2019, 300: 18-26.
|
| [49] |
Xue R, Wang J, Yang L, et al. Coenzyme Q10 ameliorates pancreatic fibrosis via the ROS-Triggered mTOR signaling pathway [J]. Oxid Med Cell Longev, 2019, 2019: 8039694.
|
| [50] |
Xue R, Yang J, Wu J, et al. Coenzyme Q10 inhibits the activation of pancreatic stellate cells through PI3K/AKT/mTOR signaling pathway[J]. Oncotarget, 2017, 8(54): 92300-92311.
|
| [51] |
Berna M J, Seiz O, Nast J F, et al. CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production[J]. J Biol Chem, 2010, 285(50): 38905-38914.
|
| [52] |
Tsang S W, Zhang H J, Chen Y G, et al. Eruberin A, a natural flavanol glycoside, exerts anti-fibrotic action on pancreatic stellate cells[J]. Cell Physiol Biochem, 2015, 36(6): 2433-2446.
|
| [53] |
Boulling A, Masson E, Zou W B, et al. Identification of a functional enhancer variant within the chronic pancreatitis-associated SPINK1 c.101A>G (p.Asn34Ser)-containing haplotype[J]. Hum Mutat, 2017, 38(8): 1014-1024.
|
| [54] |
Qian Y Y, Zou W B, Chen J M, et al. Identification of a novel SPINK1 deletion in a teenager with idiopathic chronic pancreatitis[J]. Dig Liver Dis, 2017, 49(8): 941-943.
|
| [55] |
Wang D, Xin L, Lin J H, et al. Identifying miRNA-mRNA regulation network of chronic pancreatitis based on the significant functional expression[J]. Medicine (Baltimore), 2017, 96(21): e6668.
|
| [56] |
Hegyi E, Sahin-Tóth M. Genetic risk in chronic pancreatitis: The trypsin-dependent pathway [J]. Dig Dis Sci, 2017, 62(7): 1692-1701.
|
| [57] |
Weiss F U, Skube M E, Lerch M M. Chronic pancreatitis: an update on genetic risk factors[J]. Curr Opin Gastroenterol, 2018, 34(5): 322-329.
|
| [1] |
. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(8): 718-719. |
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2019, Vol. 30 
