老年慢性心力衰竭患者血浆CTGF、iPTH、甲状腺激素水平与心功能的相关性

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Abstract Objective To investigate the values of plasma CTGF, iPTH, thyroid hormones,NT-proBNP, and LVMI in elderly patients with chronic heart failure and their correlations with cardiac function. Methods A total of 120 cases of elderly patients with chronic heart failure treated in our hospital between June 2016 and December 2017 were selected as the case group, whose plasma CTGF, iPTH, thyroid hormones, NT-proBNP and LVMI were detected.According to the NYHA cardiac function classification standard, these patients were divided into grade Ⅱ, Ⅲ,and Ⅳ groups, with 40 cases in each. Another 40 healthy elderly patients treated in the same period were selected as the control group.The levels of plasma CTGF, iPTH, thyroid hormones,NT-proBNP and LVMI were compared between the four groups. Spearman correlation was used to analyze the correlations between plasma CTGF, iPTH, thyroid hormones, NT-proBNP, LVMI and cardiac function grading in patients with chronic heart failure. Results ①The levels of plasma CTGF, iPTH, NT-proBNP and LVMI in grade Ⅱ, Ⅲ and Ⅳ groups were significantly higher than those in the control group (P＜0.01). These levels increased with the grade. The difference was statistically significant (P＜0.05).②The level of FT3 in grade Ⅱ, Ⅲ and Ⅳ groups was significantly lower than that in the control group (P＜0.01),which decreased with the grade, and the difference was statistically significant (P＜0.05).③The results of Spearman correlation analysis indicated that there was a positive correlation between plasma CTGF, iPTH, NT-proBNP,LVMI and cardiac function grading (ρ>0.6,P＜0.05). FT3 was negatively correlated with cardiac function grading (ρ>-0.6,P＜0.05).④ The results of Pearson correlation analysis showed that plasma CTGF, iPTH,NT-proBNP and LVMI were positively correlated (r>0.6,P＜0.05). FT3 was negatively correlated with LVMI (r<-0.6,P＜0.05). Conclusions Plasma CTGF, iPTH, FT3, NT-proBNP and LVMI are strongly correlated with cardiac function grading in elderly patients with chronic heart failure, which can be used as important indicators for clinical diagnosis and condition evaluation of chronic heart failure.

Key words： chronic heart failure CTGF iPTH thyroid hormone cardiac function

Received: 20 December 2018

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	WEN Fangmei
	CHENG Xinchun

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WEN Fangmei,CHENG Xinchun. Plasma CTGF, iPTH and thyroid hormones in elderly patients with chronic heart failure[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(4): 299-302.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I4/299

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