不同危重程度的脓毒血症患者血清甲状腺激素水平的变化与预后的关系

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Abstract Objective To explore the relationships between dynamic changes of thyroid hormone levels and prognosis in patients with ICU sepsis.Methods A total of 172 patients with sepsis diagnosed according to the diagnostic criteria of the ICU and admitted to our hospital between January 2015 and August 2017 were selected as the subjects (the case group). According to the APACHE Ⅱ score, these patients were divided into the sepsis group (72 cases), severe sepsis group (62 cases), and septic shock patients (38 cases), while another 73 patients from ordinary wards were selected as the control group. The case group was again divided into the survival group and death group according to the patients’ survival 28 days after admission to the ICU. The thyroid gland was treated at different time points. Hormone levels were monitored and correlations of thyroid hormone levels with different prognostic outcomes and APACHE Ⅱ scores were studied.Results The levels of T₃, T₄, FT₃, FT₄, and TSH in the 24 h, 4 d, and 10 d cases were significantly lower than those in the control group (P<0.05). These levels in the septic shock group were significantly higher than those in the control group. They increased with the prolongation of ICU stay in the case group, and were significantly lower in the death group than in the survival group. Correlation analysis showed that the APACHE Ⅱ score was negatively correlated with T₃, T₄, FT₃, FT₄ and TSH levels (P<0.05), while PCT and CRP levels showed a positive correlation (P<0.05).Conclusion The level of thyroid hormone in patients with ICU sepsis is significantly reduced, depending on the severity of the disease. Monitoring thyroid hormone levels can help clinical treatment and improve prognosis of patients.

Key words： sepsis thyroid hormone ICU prognosis

Received: 20 September 2018

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	JIA Xiaowei
	WANG Jiaxing
	DUAN Kun

Cite this article:

JIA Xiaowei,WANG Jiaxing,DUAN Kun. Changes of serum thyroid hormone levels and prognosis in patients with sepsis of varied severity[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(5): 383-387.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I5/383

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