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| Effect of blood cholesterol levels on survival of patients with multiple myeloma |
| DONG Yuehua1, LIANG Yan2, YAN Huaining3 |
1.Department of Internal Medicine, Beijing Municipal Corps Hospital of PAP, Beijing 100027, China;
2.Pharmacy,the Third Medical Center of Chinese PLA General Hospital,Beijing 100039, China;
3.Jiangsu Provincial Corps Hospital, Chinese People’s Armed Police Force, Yangzhou 225003, China |
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Abstract Objective To explore the effects of blood cholesterol levels on the survival of patients with multiple myeloma.Methods One hundred and thirty-six patients with multiple myeloma who were treated in the hospital between June 2014 and September 2017 were selected as the observation group, while another eighty-two healthy physical examinees were selected as the control group. Relevant data was collected and retrospectively analyzed.Results Serum levels of total cholesterol [(2.67±1.12) mmol/L], low-density lipoprotein [(1.62±0.98) mmol/L], apolipoprotein B [(0.45±0.28) mmol/L] and high-density lipoprotein [(0.81±0.28) mmol/L] were significantly lower in the observation group than in the control group (P<0.05). The survival rate of stage Ⅲ patients was significantly lower than that of stage Ⅰ and stage Ⅱ patients (P<0.05). Low-density lipoprotein levels [(1.38±0.56) mmol/L] were the lowest in patients with IgA multiple myeloma, but [(2.25±0.43) mmol/L] were the highest in patients with light-chain multiple myeloma (P<0.05).Conclusion The development and survival of multiple myeloma are closely related to blood cholesterol levels that depend on the intake of low-density lipoprotein. Low blood cholesterol levels can lead to the deterioration of a patient’s condition and drug resistance, which negatively affects patients’ survival and quality of life.
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Received: 20 December 2018
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2019, Vol. 30 
