质子泵抑制药和H<sub>2</sub>受体拮抗药预防应激性溃疡有效性和安全性的Meta分析

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Abstract Objective To compare the curative effect and safety of proton pump inhibitors (PPI) and histamine-2-receptor antagonists (H₂RAs) when used to prevent stress ulcer prophylaxis in critically ill patients.Methods Randomized controlled trials (RCTs) of PPI vs H₂RA for stress ulcer prophylaxis in patients in critical condition were retrieved from the Cochrane library, PubMed, Embase, Science Direct,CNKI and CMB databases. Key indexes included gastrointestinal (GI) bleeding, iatrogenic pneumonia, Clostridium difficile infection, mortality and length of stay in the ICU.Results Prophylactic application of PPIs can reduce the risk of clinical gastrointestinal bleeding and upper gastrointestinal bleeding compared with H₂RA.Conclusions PPIs are superior to H₂RAs in preventing GI bleeding without significantly increasing the risk of pneumonia or mortality. However,their impact on Clostridium difficile infections remains uncertain.

Key words： proton pump inhibitor histamine-2-receptor antagonist stress ulcer meta-analysis

Received: 20 November 2018

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	ZHANG Hong
	YUAN Jian
	YU Xiangli
	YE lin
	YANG Chunmei

Cite this article:

ZHANG Hong,YUAN Jian,YU Xiangli等. Efficacy and safety of proton pump inhibitors and Histamine-2-receptor antagonists for stress ulcer prophylaxis in critically ill patients: a meta-analysis of randomized trials[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(6): 510-512.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I6/510

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