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| Relationships between carotid atherosclerosis and levels of serum adiponectin and resistin in elderly patients with hypertension |
| ZHU Yaqin1,DONG Wenjing2,and ZHANG Weiwei3 |
1.Yantai Special Treatment Sanatorium of Chinese People’s Armed Police Force,Yantai 264001,China;
2. Wulanchabu Central Hospital,Wulanchabu 012000,China;
3.The Third Medical Center of PLA General Hospital,Beijing 100039,China |
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Abstract Objective To study the relationships between carotid atherosclerosis and levels of serum adiponectin and resistin in elderly patients with hypertension.Methods Correlation analysis was performed on 112 elderly patients with hypertension treated in our hospital between January 2016 and December 2017. All the patients underwent carotid artery ultrasound. According to the ultrasound results, these patients were divided into the normal group (32 cases), thickness group (42 cases) and atherosclerotic plaque group (38 cases). Serum adiponectin and resistin levels in each group were measured and compared.Results Serum adiponectin levels were negatively correlated with intima-media thickness(r=-0.562), while serum resistin levels were positively correlated(r=0.621). Insulin resistance and serum resistin levels were independent risk factors for carotid atherosclerosis, while serum adiponectin levels were protective factors for atherosclerosis.Conclusions Elderly patients with hypertension who have low serum adiponectin and high resistin levels are at higher risk of carotid atherosclerosis. For elderly patients with hypertension, monitoring serum adiponectin and resistin levels can help control carotid atherosclerosis.
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Received: 23 January 2019
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| [1] |
MotoshimaH , Wu X , Mahadev K , et al. Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL[J]. Biochemical Biophysical ResCommuni, 2004, 315(2):270-271.
|
| [2] |
Steppan C M , Bailey S T , Bhat S , et al. The hormone resistin links obesity to diabetes[J]. Nature, 2001, 409(6818):307-312.
|
| [3] |
Sinan U Y ,Canbolat I P , Baydar O , et al. Relationship between increased serum resistinlevel and severity of Coronary Artery Disease[J]. Angiology, 2014, 65(3):239-242.
|
| [4] |
夏章勇, 杨 华, 崔可密, 等. 脑卒中患者急性期血浆抵抗素和瘦素水平及其相关性研究[J]. 中华老年心脑血管病杂志, 2006, 8(5):352.
|
| [5] |
Ohashi K. Adiponectin and hypertension[J]. Am J Hypertens, 2011, 24(3):263-269.
|
| [6] |
Matsuda M, Tamura R, Kishida N, et al. Predictive value of adiponectinin patients with multivessel coronary atherosclerosis detected on computed tomography angiography[J]. J Atheroscl Thromb, 2013, 20(10):767-776.
|
| [7] |
Wang X,Pu H, Ma C, et al. Adiponectinabates atherosclerosis by reducing rxidative Stress[J]. Med Sci Monit,2014,20:1792-1800.
|
| [8] |
Dullaart R P, De V R, Van T A, et al. Lower plasma adiponectin is a marker of increased intima-media thickness associated with type 2 diabetes mellitus and with male gender[J]. Eur J Endocri,2007, 156(3):387-394.
|
| [9] |
Muse E D, Feldman D I, Blaha M J, et al. The association of resistin with cardiovascular disease in the multi-ethnic study of atherosclerosis[J]. Atherosclerosis, 2015, 239(1):101-108.
|
| [10] |
黄银琼, 李芳萍. 抵抗素与炎症、动脉粥样硬化研究进展[J]. 国际内科学杂志, 2009, 36(3):153-157.
|
| [11] |
金 铃, 龙兆丰. 抵抗素参与血管内皮细胞功能障碍的研究进展[J]. 国际内科学杂志, 2007, 34(5):289-292.
|
| [12] |
Pischon T, Girman C J, Hotamisligil G S, et al. Plasma adiponectinlevels and risk of myocardial Infarction in Men[J]. JAMA, 2004, 13(6):20.
|
| [13] |
Inoue T, Kotooka N, Morooka T, et al. High molecular weight adiponectinas a predictor of long-term clinical outcome in patients with coronary artery disease[J]. Am J Cardio, 2007, 100(4):569-574.
|
| [14] |
Hara K, Yamauchi T, Imai Y, et al. Reduced adiponectin level is associated with severity of coronary artery disease[J]. Int Heart J,2007,9(1):243.
|
| [15] |
王 欣. 老年冠心病患者血清抵抗素与脂联素水平的相关性研究[J]. 内蒙古医学杂志, 2015, 47(7):778-781.
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2020, Vol. 31 
