支气管哮喘患者血清miR-155、HP及MPO水平与肺功能的关系

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Abstract Objective To investigate the correlations between serum miR-155, HP and MPO levels and lung function in patients with bronchial asthma. Methods Sixty-two cases of bronchial asthma treated between November 2017 and September 2019 in our department were selected, 39 of whom were in the onset stage (the onset group), 23 were in the remission stage (the remission group), and another 12 health examinees were enrolled as the healthy group. The levels of serum miR-155(microRNA-155), HP (hydroxyproline) and MPO (myeloperoxidase) were measured and compared between the participants. Results The expressions of HP, MPO and miR-155 in the onset group were significantly higher than those in the healthy group (P<0.01) , and those of the remission group were significantly higher than in the healthy group (P< 0.01) The expressions of HP(mg/L), MPO(U/L)and miR-155 in the onset group were significantly higher than those of the remission group (1.97±0.98 vs 1.49±0.73, 757.28±111.63 vs 579.06±101.74, 2.89±0.93 vs 2.02±0.83,P<0.01). FVC, FEV₁, FEV₁/FVC, MMEF75/25, PEF in the onset group and remission group were significantly lower than those in the healthy group (P< 0.01), and those in the remission group were significantly lower than in the healthy group (P< 0.01). FVC(L), FEV₁(L), FEV₁/FVC(%), MMEF75/25(L/s), PEF(L/min) were significantly lower in the onset group than in the remission group (2.63±0.92 vs 3.12±0.76, 1.45±0.31 vs 1.87±0.30, 59.26±14.25 vs 73.73±10.04,0.41±0.09 vs 0.73±0.08, 138.95±15.06 vs 402.69±10.85,P<0.01). FVC, FEV₁, FEV₁/FVC, MMEF75/25, PEF were negatively correlated with HP, MPO and miR-155(P< 0.05). Conclusions The serum miR-155, HP and MPO levels of bronchial asthma are negatively correlated with lung function.

Key words： bronchial asthma miR-155 hydroxyproline myelo peroxidase pulmonary function

Received: 10 November 2019

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	YANG Xiaona
	ZHANG Ying
	HAN Xiao

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YANG Xiaona,ZHANG Ying,HAN Xiao. Relationships between serum miR-155, HP and MPO levels and lung function in patients with bronchial asthma[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(5): 414-417.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2020/V31/I5/414

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