Rui Y, Yao L, FeiLW, et al.MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer[J].World J Gastrointest Oncol, 2016, 8(4): 330-340.
[2]
Petra V F, Martin P, Lenka R, et al.Genome-wide microRNA expression profiling in primary tumors and matched liver metastasis of patients with colorectal cancer[J].Cancer Genomics Proteomics, 2016, 13: 311-316.
[3]
Dong Y, Wu W K, Wu C W,et al.MicroRNA dysregulation in colorectal cancer: a clinical perspective[J].Br J Cancer, 2011, 104: 893-898.
[4]
Chi D, Zhou D.MicroRNAs in colorectal carcinoma-from pathogenesis to therapy[J].J Exp Clin Cancer Res, 2016, 35:43.
[5]
Asanganiv I A, Rasheed S A, Nikolova D A, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer[J].Oncogene, 2008, 27: 2128-2136.
[6]
Valeri N, Gasparini P,Braconi C, et al. MicroRNA-21 induces resistance to 5-flfluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)[J].Proc Natl Acad Sci U S A, 2010, 107: 21098-21103.
[7]
Deng J, Lei W, Fu J C, et al. Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro[J].Biochem Biophys Res Commun, 2014, 443: 789-795.
[8]
Kim S A, Kim I,Yoon S K, et al. Indirect modulation of sensitivity to 5-flfluorouracil by microRNA-96 in human colorectal cancer cells[J].Arch Pharm Res, 2015, 38: 239-248.
[9]
Catela I T,Voss G,Cornella H, et al.MicroRNAs as cancer therapeutics: a step closer to clinical application[J].Cancer Lett, 2017, 407: 113-122.
[10]
Valeri N,Gasparini P, Fabbri M, et al.Modulation of mismatch repair and genomic stability by miR-155[J].Proc Natl Acad Sci U S A, 2010, 107: 6982-6987.
[11]
Rodriguez A C, Fuentes M E, Xiao L, et al. Combining anti-mir-155 with chemotherapy for the treatment of lung cancers[J]. Clin Cancer Res, 2017, 23: 2891-2904.
[12]
Ling H, Pickard K, Ivan C, et al.The clinical and biological signifificance of MIR-224 expression in colorectal cancer metastasis[J]. Gut, 2016, 65: 977-989.
[13]
CordesK R, Sheehy N T,White M P, et al. MiR-145 and miR-143 regulate smooth muscle cell fate and plasticity[J]. Nature, 2009, 460, 705-710.
[14]
Yuan F, Sun R, Li L,et al.A functional variant rs353292 in the flflanking region of miR-143/145 contributes to the risk of colorectal cancer[J].Sci Rep, 2016,6: 30195.
[15]
Banerjee N, Kim H, Talcott S, et al. Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrantcrypt foci and inflammation : possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR[J].Carcinogenesis, 2013, 34: 2814-2822.
[16]
Lee J J, Drakaki A, Iliopoulos D, et al. MiR-27b targets PPARgamma to inhibit growth, tumor progression and the inflflammatory response in neuroblastoma cells[J].Oncogene, 2012, 31: 3818-3825.
[17]
Iwaya T, Yokobori T, Nishida N, et al.Downregulation of miR-144 is associated with colorectal cancer progression via activation of mTOR signaling pathway[J]. Carcinogenesis, 2012, 33: 2391-2397.
[18]
Sun J Y, Huang Y, Li J P, et al. MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting beta-catenin[J]. Biochem Biophys Res Commun, 2012, 420: 787-792.
[19]
Li Y,Zhu X, Xu W,et al.MiR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42[J].Biochem Biophys Res Commun, 2013, 431: 560-565.
[20]
Chai J, Wang S, Han D, et al. MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase[J].Tumour Biol, 2015, 36: 1313-1321.
[21]
Xu K,Liu X, Mao X, et al. MicroRNA-149 suppresses colorectal cancer cell migration and invasion by directly targeting forkhead box transcription factor FOXM1[J]. Cell Physiol Biochem, 2015, 35: 499-515.
[22]
Toiyama Y, Hur K, Tanaka K,et al. Serum miR-200c is a novel prognostic and metastasispredictive biomarker in patients with colorectal cancer[J]. Ann Surg, 2014, 259: 735-743.
[23]
Schetter A J,Leung S Y,Sohn J J, et al. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma[J].JAMA, 2008, 299: 425-436.
[24]
Kjaer F S, Hansen T F, Nielsen B S, et al. The prognostic importance of miR-21 in stage II colon cancer: a population-based study [J].Br J Cancer, 2012, 107: 1169-1174.
[25]
Hong L C, Shao J H, Ai H L, et al. Correlation between expression of miR-155 in colon cancer and serum carcinoembryonic antigen level and its contribution to recurrence and metastasis forecast[J].Saudi Med J, 2014, 35: 547-553.
[26]
Kjersem J B, Ikdahl T, Lingjaerde O C, et al. Plasma microRNAs predicting clinical outcome in metastatic colorectal cancer patients receiving first-line oxaliplatin-based treatment[J]. Mol Oncol, 2014, 8: 59-67.
[27]
Xu K, Liang X, Cui D, et al. MiR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug sensitivity in human colorectal carcinoma cells[J]. Mol Carcinog, 2013, 52: 70-78.
[28]
Gao Y,Liu Z, Ding Z,et al.MircoRNA-155 increases colon cancer chemoresistance to cisplatin by targering forkhead box O3[J]. Oncol Lett,2018,15(4);4781-4788.
[29]
Misso G, Di M M, De R G, et al. Mir-34: a new weapon against cancer? [J].Mol Ther Nucleic Acids, 2014, 3: e194.
[30]
Tang W, Zhu Y, Gao J, et al. MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4[J]. Br J Cancer, 2014, 110: 450-458.
[31]
Zhao J,Tang N,Wu K,et al.Mir-21 simultaneously regulates ERK1 signaling in HSC activation and hepatocyte EMT in hepatic fibrosis[J].PLoS One,2014,9:e108005.
[32]
Ajay G, Oscar A T, Shu S T.Exosomal microRNA biomarkers: emerging frontiers in colorectal and other human cancers[J].Expert Rev Mol Diagn, 2016, 16(5): 553-567.
[33]
Petra V F, Alena S K, Tomas G, et al.MicroRNA biogenesis pathway genes are deregulated in colorectal cancer[J].Int J Mol Sci, 2019, 20: 4460.
2020, Vol. 31 
