青春期甲状腺功能亢进症对生长发育及精神状态的影响

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Abstract Objective To analyze the influence of adolescent hyperthyroidism on the growth and mental status of adolescents.Methods Fifty patients with adolescent hyperthyroidism treated in our hospital between January 2017 and December 2018 were selected as the observation group, while another 50 adolescents of the same age were randomly selected as the control group. Height, weight, thyroid function, serum Ca²⁺, P²⁺, ALP were measured, and PSQI, SAS and SDS questionnaires were used. The related indexes were compared between the two groups, and the correlation between FT₃, FT₄, TSH and other indexes was analyzed.Results The proportions of height<-2 SD, weight<-2 SD and BMI<18.5(kg/m²) in the observation group were significantly higher than those in the control group (P<0.05). There were no significant difference in serum Ca²⁺ or P²⁺ levels between the two groups, but the ALP level in the observation group was significantly higher than that in the control group (P<0.05). The scores of PSQI, SAS and SDS in the observation group were higher than those of the control group. The proportion of PSQI≥16, SAS≥50, SDS≥53 in the observation group was also significantly higher than that in the control group (P<0.05). Pearson correlation analysis showed that the FT4 level was positively correlated with the scores of PSQI, SAS and SDS (P<0.05).Conclusions Adolescent hyperthyroidism can affect the growth, development and mental state of adolescents. Importance should be attached to the prevention and treatment of adolescent hyperthyroidism.

Key words： adolescence hyperthyroidism growth sleep disorder anxiety depression

Received: 11 April 2020

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	Articles by authors
	DAI Hong
	ZHU Hongxia
	DONG Jia
	WU Lei
	HE Wei
	WAN Zixuan

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DAI Hong,ZHU Hongxia,DONG Jia等. Influence of adolescent hyperthyroidism on adolescent growth and mental status[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(12): 1049-1052.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2020/V31/I12/1049

[1]	Léger J, Carel J C. Diagnosis and management of hyperthyroidism from prenatal life to adolescence[J]. Best Pract Res Clin Endocrinol Metab,2018,32(4):373-386.
[2]	姜泽雯,郑孝东.甲状腺功能亢进症皮肤改变误诊为结节性红斑1例[J].武警医学,2019,30(9):797-798.
[3]	Cramon P,Winther K H,Watt T,et al. Quality-of-life impairments persist six months after treatment of graves’ hyperthyroidism and toxic nodular goiter: a prospective cohort study[J].Thyroid,2016,26 (8):1010-1018.
[4]	Conaglen H M,Tamatea J A,Conaglen J V,et al. Treatment choice, satisfaction and quality of life in patients with graves' disease[J]. Clin Endocrinol (Oxf),2018,88(6):977-984.
[5]	支朦朦,袁勇贵,李玲. 甲状腺功能与情绪及认知障碍关联的研究进展[J].东南大学学报(医学版),2016,35(4):612-616.
[6]	张霄, 杜怡峰.甲状腺功能亢进症的神经系统并发症[J].临床神经病学杂志,2016,29(4):313-315.
[7]	Hanley P,Lord K,Bauer A J.Thyroid disorders in children and adolescents: a review[J]. JAMA Pediatr, 2016,170(10):1008-1019.
[8]	Simon M, Rigou A, Moal J L, et al. Epidemiology of childhood hyperthyroidism in france: a nationwide population-based study[J]. J Clin Endocrinol Metab, 2018,103(8): 2980-2987.
[9]	Gill D S,Greening J E,Howlett T A,et al. Long-term outcome of hyperthyroidism diagnosed in childhood and adolescence: a single-centre experience[J]. J Pediatr Endocrinol Metab, 2019,32(2):151-157.
[10]	廖坷华,李妮,卢桂南.青春期甲状腺功能亢进患者骨龄及骨代谢的特点分析[J].实用医学杂志,2013, 29(6):928-930.
[11]	陈瑶,王静.青春期甲亢患者骨代谢特点分析[J].中国伤残医学,2014,22(7):115-116.
[12]	任爱芬.甲状腺亢进患者睡眠障碍的原因及护理探讨[J].中国医药指南,2018,16(7):211-212.
[13]	Medici M,Direk N,Visser W E,et al.Thyroid function within the normal range and the risk of depression: a popula-tion-based cohort study[J]. J Clin Endocrinol Metab,2014,99(4):1213-1219.
[14]	Ittermann T, Henry V, Baumeister S E, et al. Diagnosed thyroid disorders are associated with depression and anxiety[J]. Soc Psychiatry Psychiatr Epidemiol,2015,50 (9):1417-1425.
[15]	Li L, Zhi M M, Hou Z H,et al.Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional mri study[J]. Oncotarget,2017,8(4):6283-6294.
[16]	Tunç S, Köprülü Ö, Ortaç H, et al.Long-term monitoring of graves’ disease in children and adolescents: a single-center experience[J]. Turk J Med Sci, 2019,49 (2):464-471.

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