嗅神经母细胞瘤伴发神经内分泌副瘤综合征的诊疗分析

Abstract
Figure/Table
References
Related Citation (8)

Download: PDF (1658 KB) HTML (0 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To summarize the clinical diagnosis and treatment features of olfactory neuroblastoma(ONB) with paraneoplastic syndromes (PNS).Methods Four ONB patients with PNS in our department from August 2010 to August 2020 were reviewed. Their clinical data were collected. There were 2 males and 2 females, with an average age of 39.5 years. According to the modified Kadish stage, all the patients were Kadish stage C; while according to Dulguerov stage, there was 1 case of T₃ and 3 cases of T₄.Results All patients underwent endoscopic resection with negative margins. Diabetes insipidus, electrolyte disturbance and hormone changes occurred in 3 patients during the perioperative period. Postoperative complications such as cerebrospinal fluid leakage and meningitis were not found, but 1 patient had intracranial hematocele. Diabetic insipidus, ion disorders, and hormone changes generally returned to normal about 2 weeks after surgery. The follow-up time was 6-125 months, and no tumor recurrence or metastasis was observed. Hormone replacement therapy was not performed. Immunohistochemical staining showed that most of the tumor cells were positive for synaptophysin (Syn) and pheochromochrome A(ChgA), and Ki-67 staining showed cell proliferation index ranging from 1% to 50%.Conclusions ONB patients with PNS usually have insidious symptoms and need to be vigilant. These patients are prone to electrolyte disturbance and hormone level disturbance during the perioperative period. Electrolyte levels can be monitored regularly to prevent tumor recurrence.

Key words： olfactory neuroblastoma paraneoplastic syndromes endoscopic syndrome of inappropriate antidiuretic hormone ectopic ACTH secretion

Received: 11 May 2021

ZTFLH:

R739.62

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	SUN Yan
	HUANG Qian
	CUI Shunjiu
	WANG Mingjie
	ZHANG Shurong
	YANG Bentao
	QIU E
	QU Jing
	ZHOU Bing

Cite this article:

SUN Yan,HUANG Qian,CUI Shunjiu等. Clinical diagnosis and treatment analysis of olfactory neuroblastoma with paraneoplastic syndromes[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(6): 504-509.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2021/V32/I6/504

[1]	Dulguerov P, Allal A S, Calcaterra T C. Esthesioneuroblastoma: a meta-analysis and review[J]. Lancet Oncol, 2001,2(11):683-690.
[2]	Dutta R, Dubal P M, Svider P F, et al. Sinonasal malignancies: a population-based analysis of site-specific incidence and survival[J]. Laryngoscope, 2015,125(11):2491-2497.
[3]	Barinsky G L, Azmy M C, Kilic S, et al. Comparison of open and endoscopic approaches in the resection of esthesioneuroblastoma[J]. Ann Otol Rhinol Laryngol, 2021,130(2):136-141.
[4]	Fiani B, Quadri S A, Cathel A, et al. Esthesioneuroblastoma: a comprehensive review of diagnosis, management, and current treatment options[J]. World Neurosurg, 2019,126:194-211.
[5]	Kunc M, Gabrych A, Czapiewski P, et al. Paraneoplastic syndromes in olfactory neuroblastoma[J]. Contemp Oncol, 2015,19(1):6-16.
[6]	孙炎, 黄谦, 崔顺九, 等. Kadish C期嗅神经母细胞瘤行鼻内镜手术切除及综合治疗的临床分析[J].中国耳鼻咽喉颅底外科杂志,2020,26(2):114-120.
[7]	Marinelli J P, Janus J R, Van Gompel J J, et al. Esthesioneuroblastoma with distant metastases: systematic review & meta-analysis[J]. Head Neck, 2018,40(10):2295-2303.
[8]	Martinez-Perez R, Hardesty D A, Palmer J, et al. Remote leptomeningeal dissemination in olfactory neuroblastoma mimicking multiple parasagittal meningiomas: diagnostic and therapeutic challenge[J]. World Neurosurg, 2020,134:361-364.
[9]	Singh S, Singh L, Ranjan R, et al. Correlating the treatment outcome with tumor staging, grading, and various treatment modalities in patients with esthesioneuroblastoma[J]. South Asian J Cancer, 2019,8(2):124-126.
[10]	Zafereo M E, Fakhri S, Prayson R, et al. Esthesioneuroblastoma: 25-year experience at a single institution[J]. Otolaryngol Head Neck Surg, 2008,138(4):452-458.
[11]	Senchak A, Freeman J, Ruhl D, et al. Low-grade esthesioneuroblastoma presenting as SIADH: a review of atypical manifestations[J]. Case Rep Otolaryngol, 2012,11:582180.
[12]	Plasencia Y L, Cortés M B, Arencibia D M, et al. Esthesioneuroblastoma recurrence presenting as a syndrome of inappropriate antidiuretic hormone secretion[J]. Head Neck, 2006,28(12):1142-1146.
[13]	周颖, 蒙碧辉, 梁杏欢, 等. 嗅神经母细胞瘤淋巴结转移病灶伴发血管升压素不适当分泌综合征一例并文献复习[J].中国全科医学,2013,16(35):3504-3507.
[14]	Gray S T, Holbrook E H, Najm M H, et al. Syndrome of inappropriate antidiuretic hormone secretion in patients with olfactory neuroblastoma[J]. Otolaryngol Head Neck Surg, 2012,147(1):147-151.
[15]	Yu K, Roncaroli F, Kearney T, et al. Ectopic cushing's syndrome secondary to olfactory neuroblastoma[J]. Acta Neurochir (Wien), 2018,160(5):1023-1026.
[16]	潘召城, 宋琦, 芮炜玮, 等. 副鼻窦内肿瘤致异位促肾上腺皮质激素综合征二例及文献复习[J].中华放射学杂志,2019,53(1):69-72.
[17]	Kobayashi K, Asakura T, Ishii M, et al. Pulmonary nocardiosis mimicking small cell lung cancer in ectopic ACTH syndrome associated with transformation of olfactory neuroblastoma: a case report[J]. BMC Pulm Med, 2018,18(1):142.