miR-7-5p/FGFR4轴与胆囊癌患者预后的关系

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Abstract Objective To explore the relationship between the miR-7-5p/FGFR4 axis and the prognosis of patients with gallbladder cancer (GBC).Methods A total of 47 GBC patients who underwent surgery in the Characteristic Medical Center of PAP between June 2016 and June 2018 were enrolled, whose gallbladder cancer tissues (GBC group) and paracancerous tissues (PCLT group) were collected. Another 43 patients with benign gallbladder disease were selected, and their benign gallbladder tissues were collected as the control group (NC group). The mRNA levels of fibroblast growth factor receptor 4 (FGFR4) and miR-7-5p were detected by RT-qPCR. The postoperative survival was followed up. The relationship between miR-7-5p and FGFR4 mRNA expressions was analyzed. According to the expression levels of miR-7-5p or FGFR4, these patients were divided into the low expression subgroup and high expression subgroup, and the relationship between the these expression levels and the prognosis of patients with gallbladder cancer was analyzed respectively.Results Compared with the PCLT or NC group, the level of miR-7-5p mRNA in the GBC group decreased, but the level of FGFR4 mRNA increased, and the difference was statistically significant (P<0.01). When compared with the NC group, the expression level of miR-7-5p mRNA in the PCLT group decreased, while the level of FGFR4 mRNA increased, but the difference was not statistically significant (P>0.05). The expression level of miR-7-5p mRNA was negatively correlated with that of FGFR4 mRNA (r=-0.535, P=0.004). The expression level of miR-7-5p mRNA was correlated with the stage, degree of differentiation and lymphatic metastasis of gallbladder carcinoma (P=0.035, P=0.036, P=0.006). The survival rate of patients in the miR-7-5p mRNA low expression subgroup was lower than that of the high expression subgroup (P=0.047), but that of patients in the FGFR4 mRNA low expression subgroup was higher than in the high expression subgroup (P=0.033).Conclusions The miR-7-5p/FGFR4 axis may be one of the indicators that affects the prognosis of GBC.

Key words： gallbladder cancer miR-7-5p fibroblast growth factor receptor 4 prognostic survival

Received: 08 October 2021

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	WANG Meng
	HU Jinpeng
	WANG Zhenguo
	TENG Chuan

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WANG Meng,HU Jinpeng,WANG Zhenguo等. Relationships between the miR-7-5p/FGFR4 axis and prognosis of patients with gallbladder cancer[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(2): 93-97.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I2/93

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