外周血中性粒细胞/淋巴细胞比值及其与成分输血不良反应的关系

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Abstract Objective To analyze the correlations between the neutrophil to lymphocytes ratio in the peripheral blood of patients with adverse reactions caused by component transfusion and related adverse reactions.Methods The clinical data on 69 patients who had received component transfusion and developed adverse reactions between April 2018 and December 2019 was collected as the occurrence group, while the clinical data on another 72 patients who had received component transfusion without any adverse reactions in the same period served as the non-occurrence group. The levels of neutrophils, lymphocytes and the neutrophil to lymphocytes ratios were detected in both groups before blood transfusion. Regression analysis was used to determine the effect of the neutrophil to lymphocyte ratio before blood transfusion on the incidence of adverse reactions in patients with component blood transfusion, and the ROC curve was drawn to predict the value of risk of adverse reactions of component transfusion.Results The levels of neutrophils, lymphocytes and the neutrophil to lymphocyte ratio before blood transfusion in the occurrence group were higher than those in the non-occurrence group (P<0.05). The results of regression analysis showed that the overexpression of the neutrophil to lymphocytes ratio could influence the incidence of adverse reactions in component transfusion patients (OR>1, P<0.05). The area under the curve (AUC) of adverse reactions in component transfusion patients was 0.834,which was predicted by the neutrophil to lymphocyte ratio before blood transfusion , so the predictability was satisfactory.Conclusions The risk of adverse reactions among component transfusion patients may be related to the overexpression of the neutrophil to lymphocytes ratio in peripheral blood.

Key words： component transfusion adverse reactions neutrophil/lymphocyte ratio correlation

Received: 08 October 2021

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	WANG Yanjun
	ZHAO Runling
	ZHANG Wanwan
	LIU Qianwen

Cite this article:

WANG Yanjun,ZHAO Runling,ZHANG Wanwan等. Correlations between the neutrophil to lymphocytes ratio in peripheral blood and adverse transfusion reactions during blood component transfusion[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(2): 102-105.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2022/V33/I2/102

[1]	辛秀团.成分输血救治产科大出血并弥散性血管内凝血先兆的临床效果研究[J].中国临床医生杂志,2017,45(11):96-98.
[2]	王惟,李玲玲,柴婷婷,等.去白细胞成分血质量对降低输血不良反应的影响[J].临床输血与检验,2018,20(2):126-128.
[3]	Mei Z, Shi L, Wang B, et al.Prognostic role of pretreatment blood neutrophil-to-lymphocyte ratio in advanced cancer survivors: a systematic review and meta-analysis of 66 cohort studies[J].Cancer Treat Rev, 2017, 58(13):5-13.
[4]	Harvey A R, Basavaraju S V, Chung K W, et al.Transfusion-related adverse reactions reported to the National Healthcare Safety Network Hemovigilance Module, United States, 2010 to 2012[J].Transfusion, 2015, 55(4):709-718.
[5]	Shukla R V, Patel T G, Gupte S C.Time dependent release of interleukin-8 and tumor necrosis factor-α in platelet concentrate[J].Indian J Hematol Blood Transfus, 2015, 31(2):259-263.
[6]	Mirjolet C, Charon-Barra C, Ladoire S,et al.Tumor lymphocyte immune response to preoperative radiotherapy in locally advanced rectal cancer: the lymphorec study[J].Oncoimmunology, 2017, 7(3):e1396402.
[7]	Hong X, Cui B, Wang M,et al.Systemic immune-inflammation index, based on platelet counts and neutrophil-lymphocyte ratio, is useful for predicting prognosis in small cell lung cancer[J].Tohoku J Exp Med, 2015, 236(4):297-304.
[8]	Webb C, Norris A, Hands K.An acute transfusion reaction[J].Clin Med, 2018, 18(1):95-99.
[9]	Moon K M, Han M S, Rim C B,et al.Transfusion related acute lung injury after cesarean section in a patient with hellp syndrome[J].Korean J Fam Med, 2016, 37(1):71-74.
[10]	Frazier S K, Higgins J, Bugajski A,et al.Adverse Reactions to transfusion of blood products and best practices for prevention[J].Crit Care Nurs Clin North Am, 2017, 29(3):271-290.
[11]	芦璐,高阳.去白细胞红细胞输血对严重创伤患者免疫功能和炎症因子的影响[J].临床输血与检验,2019,21(4):352-355.
[12]	马仕财,郝彩红.去白细胞输血与常规输血的不良反应调查分析[J].实用临床医药杂志,2019,23(12):129-132.
[13]	张学林,王震,吕淑慧,等.NLR联合超敏 C 反应蛋白在社区获得性肺炎评估中的临床应用[J].海南医学院学报,2017,23(3):342-344.
[14]	马凌悦,胡琨,向倩,等.别嘌醇致抗中性粒细胞胞浆抗体相关性小血管炎肾损害患者药物超敏反应综合征的病例分析[J].中国临床药理学杂志,2018,34(3):345-347.
[15]	张劼,龚齐.不同分型慢性鼻-鼻窦炎患者外周血嗜酸性粒细胞与中性粒细胞百分比及变态反应临床差异性分析[J].山东大学耳鼻喉眼学报,2018,32(3):54-57.
[16]	李小静,李志锋,李显平.白芍总苷胶囊联合NB-UVB治疗银屑病临床观察及其对患者外周血T淋巴细胞免疫功能的影响[J].中国皮肤性病学杂志,2016,30(11):1205-1207.
[17]	孙梅琴,彭漪,徐维芳,等.冠状动脉介入治疗对急性冠状动脉综合征白细胞介素-37、超敏C反应蛋白、单核细胞及中性粒细胞与淋巴细胞比值的影响[J].中国现代医学杂志,2016,26(8):44-47.
[18]	宋杨梅,樊勇,艾比拜·玉素甫,等.甲状腺癌术前中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值与临床病理特征及预后关系研究[J].中国全科医学,2015,21(15):1748-1752.
[19]	高鹏,Gibson P G,Baines K J,等.抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降[J].中华结核和呼吸杂志,2016,39(11):898-898.
[20]	Sun B, Zhu L, Tao Y,et al.Characterization and allergic role of IL-33-induced neutrophil polarization[J].Cell Mol Immunol, 2018, 15(8):782-793.