Risk factors analysis and preoperative prediction value of central lymph node metastasis in patients with papillary thyroid cancer and Hashimoto's thyroiditis
SUN Jiajia1, ZHOU Guanglei1, REN Hanxiao2
1. Department of General Surgery, Characteristics Medical Center of Chinese People's Armed Police Force,Tianjin 300162, China; 2. Laboratory Medicine Center, the Second Hospital of Shandong University, Jinan 250033, China
AbstractObjective To investigate the risk factors and preoperative prediction value of central lymph node metastasis in patients with papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT).Methods A retrospective analysis was conducted on the basic information, preoperative ultrasound features, and thyroid function of 257 PTC patients with HT admitted to Characters Medical Center of Chinese People's Armed Police Force from January 2020 to December 2022. The patients were divided into two groups based on the presence or absence of central lymph node metastasis. Multivariate logistic regression analysis was used to explore the risk factors affecting central lymph node metastasis.Results Among the 257 PTC patients, 118 (45.91%) cases had central lymph node metastasis. Compared with the patients without central lymph node metastasis, patients with central lymph node metastasis had higher levels of serum TGAb (P=0.000) and lower levels of serum TPOAb (P=0.00). Multivariate logistic regression analysis showed that the tumor location (central OR=2.162,95%CI: 1.892-2.470, P=0.000, lower OR=6.763,95%CI: 3.647-12.53, P=0.000) and the central lymph node margin were irregular (OR=3.535,95% CI: 1.303-9.586, P=0.013); Microcalcification of central lymph nodes (OR=9.916,95%CI:5.264-18.67,P=0.000) and elevated serum TGAb levels (OR=7.124,95%CI:1.560-1.905, P=0.000) were independent risk factors for central lymph node metastasis in PTC with HT patients.Conclusions Preoperative ultrasound features combined with serum TGAb levels can predict central lymph node metastasis in patients with PTC and HT.
SUN Jiajia,ZHOU Guanglei,REN Hanxiao. Risk factors analysis and preoperative prediction value of central lymph node metastasis in patients with papillary thyroid cancer and Hashimoto's thyroiditis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(9): 737-741.
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2023, Vol. 34 
