甲状腺乳头状癌伴桥本甲状腺炎患者中央淋巴结转移的危险因素及术前预测价值

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Abstract Objective To investigate the risk factors and preoperative prediction value of central lymph node metastasis in patients with papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT).Methods A retrospective analysis was conducted on the basic information, preoperative ultrasound features, and thyroid function of 257 PTC patients with HT admitted to Characters Medical Center of Chinese People's Armed Police Force from January 2020 to December 2022. The patients were divided into two groups based on the presence or absence of central lymph node metastasis. Multivariate logistic regression analysis was used to explore the risk factors affecting central lymph node metastasis.Results Among the 257 PTC patients, 118 (45.91%) cases had central lymph node metastasis. Compared with the patients without central lymph node metastasis, patients with central lymph node metastasis had higher levels of serum TGAb (P=0.000) and lower levels of serum TPOAb (P=0.00). Multivariate logistic regression analysis showed that the tumor location (central OR=2.162,95%CI: 1.892-2.470, P=0.000, lower OR=6.763,95%CI: 3.647-12.53, P=0.000) and the central lymph node margin were irregular (OR=3.535,95% CI: 1.303-9.586, P=0.013); Microcalcification of central lymph nodes (OR=9.916,95%CI:5.264-18.67,P=0.000) and elevated serum TGAb levels (OR=7.124,95%CI:1.560-1.905, P=0.000) were independent risk factors for central lymph node metastasis in PTC with HT patients.Conclusions Preoperative ultrasound features combined with serum TGAb levels can predict central lymph node metastasis in patients with PTC and HT.

Key words： thyroid cancer central lymph node metastasis non-invasive risk factors

Received: 06 March 2023

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	SUN Jiajia
	ZHOU Guanglei
	REN Hanxiao

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SUN Jiajia,ZHOU Guanglei,REN Hanxiao. Risk factors analysis and preoperative prediction value of central lymph node metastasis in patients with papillary thyroid cancer and Hashimoto's thyroiditis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(9): 737-741.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I9/737

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