全周期综合干预对风湿免疫性疾病患者妊娠结局的影响

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Abstract Objective To explore the effect of whole-cycle comprehensive intervention on pregnancy outcomes of patients with rheumatic immune diseases (RID). Methods A total of 51 pregnant women with RID admitted to the Seventh Medical Center of PLA General Hospital from January 2021 to May 2022 were selected as the study group, which was intervened with the whole-cycle comprehensive intervention methods and diagnosis and treatment process established by our research team. At the same time, 55 cases of pregnant women with RID admitted to the hospital from January 2015 to December 2020 were selected as the control group. The differences of pregnancy outcomes among the two groups were compared. Results The incidences of preeclampsia (5.89%), fetal growth restriction (3.92%), preterm delivery (15.69%), original disease activity or aggravation (1.96%) in the study group were significantly lower than those in the control group (20.00%, 16.36%, 32.73%, 12.73%, P<0.05). The levels of complement C₃ (0.80±0.15) and C₄ (0.11±0.03) in the control group were significantly lower than those in the study group (1.07±0.21, 0.22±0.05, P<0.01), and the positive rates of immune indicators antinuclear antibody (35.29%), anti SM antibody (9.80%), anti dsDNA antibody (15.67%), anti cardiolipin antibody (23.53%), anti β₂ Glycoprotein I antibody (19.61%), anti SSA antibody (11.76%), anti SSB antibody (7.84%) in the study group were significantly lower than those in the control group (72.73%, 27.27%, 32.73%, 41.82%, 40%, 27.27%, 23.64%, P<0.05). The selective cesarean section rate (35.29%) in the study group were significantly higher than those in the control group (18.18%, P<0.05), while the total cesarean section rate (41.18%) and the cesarean section rate during labor (5.88%) were significantly lower than those in the control group (61.82%, 43.64%, P<0.05). The incidences of postpartum hemorrhage (3.92%), premature rupture of membranes (7.84%), fetal distress (5.88%) and cephalopelvic disproportion (3.92%) in the study group were significantly lower than those in the control group (16.36, 23.64%, 20.00%, 18.18%, P<0.05). The incidences of NICU admission (3.92%) and neonatal infection (9.80%) in the study group were significantly lower than those in the control group (18.18%, 27.27%, P<0.05). Conclusions The whole-cycle comprehensive intervention method can improve the maternal and fetal pregnancy outcomes and reduce the cesarean section rate.

Key words： rheumatic immune diseases pregnancy outcome comprehensive intervention methods pregnancy complication

Received: 09 April 2023

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	WANG Jing
	DONG Xing
	WANG Xin
	BAI Yunjing
	LIU Change
	ZHANG Minyu
	YANG Changshuan
	ZHANG Jie
	SHANG Lixin

Cite this article:

WANG Jing,DONG Xing,WANG Xin等. Effect of whole-cycle comprehensive intervention on pregnancy outcomes in patients with rheumatic immune diseases[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(11): 963-967.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2023/V34/I11/963

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