Comparison of patient controlled intravenous analgesia with dezocine and sufentanil following resection of colon cancer
YANG Yanjun1, ZHU Pingzeng1, HAN Xueping2,JIAO Yan1, and ZHANG Jintao3.
1.Department of Anesthesiology,Henan Provincial Corps Hospital of Chinese People’s Armed Police Forces, Zhengzhou 450052, China;2.Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052,China; 3.The Luohe Regiment Medical Team, Henan Provincial Corps of CAPF, Luohe 462000,China
Abstract：Objective To compare the efficacy and safety of dezocine and sufentanil in patient controlled intravenous analgesia following resection of colon cancer. MethodsSixty patients scheduled for resection of colon cancer, aged 42 to 70, ASAⅠ～Ⅱ, were randomly arranged into dezocine group(group D) and sufentanil group (group S)of 30 patients each. All the patients were given general anesthesia and treated with patient controlled intravenous analgesia (PCIA) towards the end of operation. PCIA gradients used for group D and group S were decozine 0.8 mg/kg and sufentanil 2 μg/kg, respectively, which were diluted to 100 ml by adding saline. VAS, Ramsay scores(3 h, 6 h, 12 h, 24 h, 48 h after operation), pressing times of PCA equipment and adverse effects were recorded and compared. ResultsThere was no significant difference in the VAS scores and pressing times of PCA equipment (P>0.05) . The Ramsay scores and adverse effects in group D were significantly lower than those in group S (P<0.05). ConclusionsDezocine in PCIA following resection of colon cancer exhibits good effect of analgesia and minor adverse reactions, which can serve as a safe and more effective method of analgesia.
林传尧,岳云,柳娟.舒芬太尼术后病人自控静脉镇痛的观察［J］.临床麻醉学杂志,2004,20(1):51-52.［2］徐建国,吴新民,罗爱伦, 等.成人术后疼痛处理专家共识［J］.临床麻醉学，2010,26(3):190-196.［3］周颖，胡海珍，宝音，等.硬膜外吗啡起前镇痛联合静脉自控镇痛在下肢骨科手术的应用［J］.武警医学,2011,22(10):839-841.［4］Thomson I R,Harding G,Hudson R J.A comparison of fentanyl and sufentanil in patients undergoing coronary artery by passgraft surgery ［J］.J Cardiothorac Vasc Anesth,2000,14(6):652-653.［5］〖JP4〗Thomas J,Cosmo A.Di Fazio ventilatory and analgesic effects of dezocine in humans［J］.Anesthesiology，1984， 61(6):716-722.〖JP〗［6］段砺瑕,李晓玲.地佐辛注射液的药理作用及临床应用［J］.中国新药杂志，2004,13(9):851-852．［7］刘萍,黄红,栗俊.地佐辛超前镇痛在妇科腹腔镜手术中的应用［J］.昆明医学院学报，2010,31(10):57-60.［8］杨宝峰,苏定冯.药理学［M］.北京:人民卫生出版社,2003：180.
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林传尧,岳云,柳娟.舒芬太尼术后病人自控静脉镇痛的观察［J］.临床麻醉学杂志,2004,20(1):51-52.［2］徐建国,吴新民,罗爱伦, 等.成人术后疼痛处理专家共识［J］.临床麻醉学，2010,26(3):190-196.［3］周颖，胡海珍，宝音，等.硬膜外吗啡起前镇痛联合静脉自控镇痛在下肢骨科手术的应用［J］.武警医学,2011,22(10):839-841.［4］Thomson I R,Harding G,Hudson R J.A comparison of fentanyl and sufentanil in patients undergoing coronary artery by passgraft surgery ［J］.J Cardiothorac Vasc Anesth,2000,14(6):652-653.［5］〖JP4〗Thomas J,Cosmo A.Di Fazio ventilatory and analgesic effects of dezocine in humans［J］.Anesthesiology，1984， 61(6):716-722.〖JP〗［6］段砺瑕,李晓玲.地佐辛注射液的药理作用及临床应用［J］.中国新药杂志，2004,13(9):851-852．［7］刘萍,黄红,栗俊.地佐辛超前镇痛在妇科腹腔镜手术中的应用［J］.昆明医学院学报，2010,31(10):57-60.［8］杨宝峰,苏定冯.药理学［M］.北京:人民卫生出版社,2003：180.
