Effect of tacrolimus and cyclosporine on glucose metabolism in rats
AN Jun1,2,XU Chun2,NIU Yujian3,WANG Hongyu2,and TENG Yaqin2.
1. Xuzhou Medical University, Xuzhou 230000, China; 2. Department of Endocrinology, General Hospital of Chinese Armed Police Forces, Beijing 100039,China； 3. Organ Transplantation Institute, General Hospital of Chinese Armed Police Forces, Beijing 100039,China
Abstract：Objective To compare the effect of tacrolimus and cyclosporine on glucose metabolism in rats. Methods SD rats were randomly divided into 3 groups. Rats in control group were administrated with distilled water 1 ml/（kg·d）. Those in cyclosporine group were administrated with cyclosporine 25 mg/（kg·d） while those in tacrolimus goup were administrated with tacrolimus 2 mg/（kg·d）. The medicine was administrated through the stomach tube. The experiment lasted 5 months. Fasting blood glucose levels and insulin levels were tested at the end of the experiment. The insulin resistance index and insulin sensitivity index were calculated. Results After 5 months of treatment, fasting blood glucose levels and the insulin resistance index in cyclosporine group and tacrolimus group were higher than those in control group（P＜0.05, individually）. The insulin sensitivity index in cyclosporine group and tacrolimus group was lower than that in control group（P＜0.05, individually）. The rats in tacrolimus group showed higher blood glucose levels, a higher insulin resistance index and lower insulin sensitivity index than those in cyclosporine group（P＜0.05, individually）. Conclusion The therapeutic dose of tacrolimus or cyclosporine has effect on blood glucose metabolism. Tacrolimus has better hyperglycemic effect than cyclosporine.
安 军,徐 春,牛玉坚,王宏宇,滕雅芹. 他克莫司和环孢素A对大鼠升血糖作用的比较[J]. 武警医学, 2012, 23(9): 776-778.
AN Jun,XU Chun,NIU Yujian,WANG Hongyu,and TENG Yaqin.. Effect of tacrolimus and cyclosporine on glucose metabolism in rats. Med. J. Chin. Peop. Armed Poli. Forc., 2012, 23(9): 776-778.
2012, Vol. 23 
