Abstract：Objective To investigate the correlation between caveolin-1 expression and clinicopathological factors and prognosis in patients with human breast carcinoma. Methods Using immunnohistochemistry to analyze the caveolin-1 expression in 168 patients with human breast carcinoma and adjacent normal breast tissue. The relationship of caveolin-1 expression and clinicopathological factors were analyzed using statistical software Prism 5.0. Results The expression of caveolin-1 in breast carcinoma was significantly lower than that in adjacent normal tissues (P＜0.01).The caveolin-1 expression was significantly correlated with advancing clinical stage(P=0.044),presence of maxillary lymph node matastasis(P=0.039),and the increase of HER-2 positive(P=0.014). The difference between groups was statistically significant (P＜0.01).The patients with breast carcinoma and positive expression of caveolin-1 had a higher five-year survival rate(P=0.018). The expression of caveolin-1 was not correlated with tumor size,age of the patients and histological grade. Conclusions The expression of caveolin-1 may be involved in the occurrence and development process of breast carcinoma.The expression of caveolin-1 has a certain relationship with clinicopathological factors in breast carcinoma. It may play a role of tumor inhibiting factor in breast carcinoma progression.
杨 光,高万峰,叶圣权,曾宪阳. 小凹蛋白-1在乳腺癌组织中的表达及其与乳腺癌浸润转移的关系[J]. 武警医学, 2013, 24(5): 379-382.
YANG Guang,GAO Wanfeng,YE Shengquan,and ZENG Xianyang. Expression of caveolin-1 in breast carcinoma and its correlation with infiltration and metastasis of breast carcinoma. Med. J. Chin. Peop. Armed Poli. Forc., 2013, 24(5): 379-382.
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2013, Vol. 24 
