Abstract：Objective To study the effect of different dose atorvastatin on carotid atherosclerosis.Methods Eight hundred and sixty old patients with carotid atherosclerosis were randomized into atorvastatin 20 mg group (group A, n=420) and atorvastatin 10 mg group (group B, n=440) for six months. Intima-media thickness(IMT) of carotid artery, hs-CRP, serum lipids were detected before and after treatment for six months. Results IMT of carotid artery, hs-CRP, serum lipids in group A were reduced significantly after theatment compared with those before treatment, and in group A were reduced significantly compared with group B.Overall incidence of cardio-and cerebrovasular events in group A was 9.6% and in group B was 13.6%.Conclusions Atorvastain 20 mg treatment in delaying and reversing the progression of carotid atherosclerosis,and reducing cardio-and cerebrovascular events is superior to atorvastatin 10 mg treatment.
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